Rzadkowska Marzena, Szacoń Elzbieta, Matosiuk Dariusz, Kedzierska Ewa, Fidecka Sylwia
Department of Synthesis and Chemical Technology of Pharmaceutical Substances with Computer Modeling Unit, Lublin, Poland.
Acta Pol Pharm. 2012 Nov-Dec;69(6):1270-5.
In the reaction of ethyl N-(1-arylimidazolidine-2-ylidene) carbamic acid ester with 4-chlorobenzylamine new derivatives of 1-(1-arylimidazolidine-2-ylidene)-3-arylurea (I-VI) were obtained. Cyclic derivatives of dihydroimidazo[l ,2-a][1,3,5]trizines were synthesized by condensation of 1-(1-arylimidazolidine-2-ylidene)-3-(4-chlorobenzyl)urea with carbonyldiimidazole (CDI) (VII-XII). The effect of compounds X, XI on the central nervous system of mice in some behavioral tests was investigated.
在N-(1-芳基咪唑烷-2-亚基)氨基甲酸乙酯与4-氯苄胺的反应中，得到了1-(1-芳基咪唑烷-2-亚基)-3-芳基脲(I-VI)的新衍生物。通过1-(1-芳基咪唑烷-2-亚基)-3-(4-氯苄基)脲与羰基二咪唑(CDI)缩合合成了二氢咪唑并[l,2-a][1,3,5]三嗪的环状衍生物(VII-XII)。在一些行为测试中研究了化合物X、XI对小鼠中枢神经系统的作用。
