Merlet Nolwenn, Busseuil David, Rhéaume Éric, Tardif Jean-Claude
Montreal Heart Institute, Research Center, 5000 Belanger Est, Montreal, QC, Canada.
Antiinflamm Antiallergy Agents Med Chem. 2013;12(1):24-35. doi: 10.2174/1871523011312010005.
Although heart failure is predominantly caused by cardiovascular conditions such as hypertension, coronary heart disease and valvular heart disease, it can also be caused by adverse drug reactions. Several medications have been shown to have cardiotoxic effects. Among those therapeutic agents, anti-inflammatory drugs, including exogenous glucocorticoids, nonsteroidal anti-inflammatory drugs and biologics, which are used to treat a broad range of diseases that are associated with inflammatory processes, are widely prescribed in clinical practice. In this review, we discuss insights from experimental models on the beneficial and cardiotoxic effects of anti-inflammatory drugs.
尽管心力衰竭主要由心血管疾病如高血压、冠心病和心脏瓣膜病引起，但也可能由药物不良反应导致。已有几种药物被证明具有心脏毒性作用。在这些治疗药物中，抗炎药，包括外源性糖皮质激素、非甾体抗炎药和生物制剂，用于治疗与炎症过程相关的多种疾病，在临床实践中被广泛使用。在本综述中，我们讨论了来自实验模型的关于抗炎药有益和心脏毒性作用的见解。
