抗炎药物的心血管不良反应。

Cardiovascular adverse effects of anti-inflammatory drugs.

作者信息

Roubille Camille, Martel-Pelletier Johanne, Davy Jean-Marc, Haraoui Boulos, Pelletier Jean-Pierre

机构信息

Osteoarthritis Research Unit, University of Montreal Hospital Research Center (CRCHUM), Notre-Dame Hospital, 1560 Sherbrooke Street East, Montreal, Quebec, Canada.

出版信息

Antiinflamm Antiallergy Agents Med Chem. 2013;12(1):55-67. doi: 10.2174/1871523011312010008.

DOI:10.2174/1871523011312010008

PMID:23286294

Abstract

Anti-inflammatory drugs consist of non-steroidal anti-inflammatory drugs (NSAIDs) including non-selective nsNSAIDs, aspirin, and cyclooxygenase-2 (COX-2)-selective inhibitors also referred to as coxibs, and glucocorticoids (GCs). They are worldwide prescribed drugs for many musculoskeletal conditions, such as osteoarthritis and inflammatory rheumatic diseases. Anti-inflammatory drugs can exert deleterious effects on the cardiovascular system, excluding aspirin. NSAIDs, especially coxibs, have been demonstrated to increase cardiovascular risk and have generated many concerns leading to the reassessment of their benefit/risk ratio. GCs may also induce cardiovascular events, but evidence seems to be less clear. Before prescribing these drugs, an assessment of cardiovascular risk may be judicious. In this review, anti-inflammatory drugs, coxibs, nsNSAIDs and GCs, and the risk of cardiovascular events will be discussed.

摘要

抗炎药物包括非甾体抗炎药（NSAIDs），其中有非选择性非甾体抗炎药、阿司匹林，以及环氧化酶-2（COX-2）选择性抑制剂（也称为昔布类药物），还有糖皮质激素（GCs）。它们是全球范围内用于治疗多种肌肉骨骼疾病的处方药，如骨关节炎和炎性风湿性疾病。除阿司匹林外，抗炎药物会对心血管系统产生有害影响。非甾体抗炎药，尤其是昔布类药物，已被证明会增加心血管风险，并引发了诸多担忧，导致对其效益/风险比进行重新评估。糖皮质激素也可能诱发心血管事件，但证据似乎不太明确。在开具这些药物之前，对心血管风险进行评估可能是明智的。在本综述中，将讨论抗炎药物、昔布类药物、非选择性非甾体抗炎药和糖皮质激素以及心血管事件的风险。