Institute of Neurology, Università Cattolica, Rome, Italy.
J Stroke Cerebrovasc Dis. 2013 Oct;22(7):e250-3. doi: 10.1016/j.jstrokecerebrovasdis.2012.11.022. Epub 2013 Jan 1.
Developmental venous anomalies (DVAs) are benign embryologic vascular variants, and before the advent of computed tomography and magnetic resonance imaging were supposed to be rare conditions. Usually, DVAs are asymptomatic and accidentally discovered during routine brain imaging studies, but sometimes they can be the cause of disabling neurologic symptoms. We describe the clinical and neuroradiologic follow-up of a 62-year-old man with a history of inflammatory bowel disease (IBD) presenting with new onset epilepsy and intracranial hemorrhage caused by thrombosis of a DVA who fully recovered after treatment with oral anticoagulant therapy. Patients with IBD have an increased risk of thrombosis because of inflammatory activity and the hypercoagulable state. Here we describe the first case of DVA thrombosis in a patient with IBD, and we show clinical and neuroradiologic follow-up after anticoagulant therapy.
发育性静脉畸形(DVAs)是良性胚胎血管变异,在计算机断层扫描和磁共振成像出现之前,被认为是罕见的情况。通常,DVAs 是无症状的,在常规脑部成像研究中偶然发现,但有时它们可能是导致致残性神经症状的原因。我们描述了一位 62 岁男性的临床和神经影像学随访情况,该患者有炎症性肠病(IBD)病史,表现为新发性癫痫发作和由 DVA 血栓形成引起的颅内出血,经口服抗凝治疗后完全恢复。患有 IBD 的患者由于炎症活动和高凝状态而增加血栓形成的风险。在这里,我们描述了 IBD 患者 DVA 血栓形成的首例病例,并展示了抗凝治疗后的临床和神经影像学随访。