Division of Biology, California Institute of Technology, Pasadena, CA 91125, United States.
Semin Cell Dev Biol. 2013 Feb;24(2):95-100. doi: 10.1016/j.semcdb.2012.12.006. Epub 2012 Dec 31.
Neural crest cells are an important cell type present in all vertebrates, and elaboration of the neural crest is thought to have been a key factor in their evolutionary success. Genomic comparisons suggest there were two major genome duplications in early vertebrate evolution, raising the possibility that evolution of neural crest was facilitated by gene duplications. Here, we review the process of early neural crest formation and its underlying gene regulatory network (GRN) as well as the evolution of important neural crest derivatives. In this context, we assess the likelihood that gene and genome duplications capacitated neural crest evolution, particularly in light of novel data arising from invertebrate chordates.
神经嵴细胞是所有脊椎动物中一种重要的细胞类型，神经嵴的形成被认为是它们进化成功的关键因素。基因组比较表明，早期脊椎动物进化过程中发生了两次主要的基因组加倍，这增加了神经嵴进化是由基因加倍所促进的可能性。在这里，我们回顾了早期神经嵴形成及其潜在的基因调控网络（GRN）的过程，以及重要的神经嵴衍生物的进化。在这种情况下，我们评估了基因和基因组加倍使神经嵴进化成为可能的可能性，特别是鉴于无脊椎脊索动物产生的新数据。
