Strupp M
Neurologische Klinik und Deutsches Schwindelzentrum, Klinikum der Universität München, Campus Großhadern, Marchionistr. 15, 81377 München.
Ophthalmologe. 2013 Jan;110(1):7-15. doi: 10.1007/s00347-012-2573-4.
The spectrum of diagnoses of patients with dizziness as the leading symptom who consult a neurologist does not differ greatly from the spectrum of those who consult ear nose and throat (ENT) specialists or general practitioners (GP). The most frequent forms are benign paroxysmal positioning vertigo (BPPV), phobic postural vertigo, central vertigo disorders, Menière's disease, vestibular neuritis and bilateral vestibulopathy. However, the first and most important question that is posed to neurologists is whether it is a central or peripheral syndrome. In more than 90 % of cases this differentiation is possible by taking the patient history (asking about the type of vertigo, the duration, triggers and accompanying symptoms) and conducting a physical examination of the patient. In the case of acute vertigo disorders in particular, a five-step procedure has proved to be helpful: the cover test to look for skew deviation as the central sign and component of the ocular tilt reaction, an examination with and without Frenzel's goggles to differentiate between peripheral vestibular spontaneous nystagmus and central fixation nystagmus, an examination of smooth pursuit and gaze-holding function and finally the head-impulse test to look for a deficit in the vestibulo-ocular reflex (VOR). Considerable advances have been made in the treatment of vertigo disorders in the last 10 years, e.g., cortisone for the treatment of acute vestibular neuritis, betahistine as a high-dosage, long-term treatment for Menière's disease, carbamazepine to treat vestibular paroxysmia and aminopyridine for downbeat nystagmus and episodic ataxia type 2.
以头晕为主要症状并咨询神经科医生的患者的诊断范围,与咨询耳鼻喉科(ENT)专家或全科医生(GP)的患者的诊断范围并无太大差异。最常见的类型是良性阵发性位置性眩晕(BPPV)、恐惧性姿势性眩晕、中枢性眩晕障碍、梅尼埃病、前庭神经炎和双侧前庭病。然而,向神经科医生提出的首要且最重要的问题是,这是中枢性还是周围性综合征。在超过90%的病例中,通过询问患者病史(询问眩晕类型、持续时间、诱因和伴随症状)并对患者进行体格检查,这种区分是可行的。特别是在急性眩晕障碍的情况下,一种五步程序已被证明是有帮助的:遮盖试验以寻找作为眼倾斜反应的中枢体征和组成部分的斜视偏差,使用和不使用Frenzel眼镜进行检查以区分周围性前庭自发性眼球震颤和中枢性注视性眼球震颤,检查平稳跟踪和凝视保持功能,最后进行头部脉冲试验以寻找前庭眼反射(VOR)缺陷。在过去10年中,眩晕障碍的治疗取得了相当大的进展,例如,使用皮质醇治疗急性前庭神经炎,使用倍他司汀作为梅尼埃病的高剂量长期治疗药物,使用卡马西平治疗前庭阵发性发作,以及使用氨基吡啶治疗下跳性眼球震颤和发作性共济失调2型。