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[眩晕与头晕:神经科医生的观点]

[Vertigo and dizziness: the neurologist's perspective].

作者信息

Strupp M

机构信息

Neurologische Klinik und Deutsches Schwindelzentrum, Klinikum der Universität München, Campus Großhadern, Marchionistr. 15, 81377 München.

出版信息

Ophthalmologe. 2013 Jan;110(1):7-15. doi: 10.1007/s00347-012-2573-4.

DOI:10.1007/s00347-012-2573-4
PMID:23288313
Abstract

The spectrum of diagnoses of patients with dizziness as the leading symptom who consult a neurologist does not differ greatly from the spectrum of those who consult ear nose and throat (ENT) specialists or general practitioners (GP). The most frequent forms are benign paroxysmal positioning vertigo (BPPV), phobic postural vertigo, central vertigo disorders, Menière's disease, vestibular neuritis and bilateral vestibulopathy. However, the first and most important question that is posed to neurologists is whether it is a central or peripheral syndrome. In more than 90 % of cases this differentiation is possible by taking the patient history (asking about the type of vertigo, the duration, triggers and accompanying symptoms) and conducting a physical examination of the patient. In the case of acute vertigo disorders in particular, a five-step procedure has proved to be helpful: the cover test to look for skew deviation as the central sign and component of the ocular tilt reaction, an examination with and without Frenzel's goggles to differentiate between peripheral vestibular spontaneous nystagmus and central fixation nystagmus, an examination of smooth pursuit and gaze-holding function and finally the head-impulse test to look for a deficit in the vestibulo-ocular reflex (VOR). Considerable advances have been made in the treatment of vertigo disorders in the last 10 years, e.g., cortisone for the treatment of acute vestibular neuritis, betahistine as a high-dosage, long-term treatment for Menière's disease, carbamazepine to treat vestibular paroxysmia and aminopyridine for downbeat nystagmus and episodic ataxia type 2.

摘要

以头晕为主要症状并咨询神经科医生的患者的诊断范围,与咨询耳鼻喉科(ENT)专家或全科医生(GP)的患者的诊断范围并无太大差异。最常见的类型是良性阵发性位置性眩晕(BPPV)、恐惧性姿势性眩晕、中枢性眩晕障碍、梅尼埃病、前庭神经炎和双侧前庭病。然而,向神经科医生提出的首要且最重要的问题是,这是中枢性还是周围性综合征。在超过90%的病例中,通过询问患者病史(询问眩晕类型、持续时间、诱因和伴随症状)并对患者进行体格检查,这种区分是可行的。特别是在急性眩晕障碍的情况下,一种五步程序已被证明是有帮助的:遮盖试验以寻找作为眼倾斜反应的中枢体征和组成部分的斜视偏差,使用和不使用Frenzel眼镜进行检查以区分周围性前庭自发性眼球震颤和中枢性注视性眼球震颤,检查平稳跟踪和凝视保持功能,最后进行头部脉冲试验以寻找前庭眼反射(VOR)缺陷。在过去10年中,眩晕障碍的治疗取得了相当大的进展,例如,使用皮质醇治疗急性前庭神经炎,使用倍他司汀作为梅尼埃病的高剂量长期治疗药物,使用卡马西平治疗前庭阵发性发作,以及使用氨基吡啶治疗下跳性眼球震颤和发作性共济失调2型。

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In vivo visualized endolymphatic hydrops and inner ear functions in patients with electrocochleographically confirmed Ménière's disease.电反应测听法确诊梅尼埃病患者的内淋巴积水与内耳功能的活体可视性研究。
Otol Neurotol. 2012 Aug;33(6):1040-5. doi: 10.1097/MAO.0b013e31825d9a95.
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4-aminopyridine and cerebellar gait: a retrospective case series.4-氨基吡啶与小脑性步态:一项回顾性病例系列研究
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Clinical, electrophysiological, and MRI findings in patients with cerebellar ataxia and a bilaterally pathological head-impulse test.
小脑性共济失调患者双侧病理头脉冲试验的临床、电生理和 MRI 表现。
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A randomized trial of 4-aminopyridine in EA2 and related familial episodic ataxias.EA2 及相关家族性发作性共济失调患者中 4-氨基吡啶的随机试验。
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High-dosage betahistine dihydrochloride between 288 and 480 mg/day in patients with severe Menière's disease: a case series.高剂量盐酸倍他司汀(288-480mg/天)治疗重度梅尼埃病患者:病例系列。
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Corticosteroids for the treatment of idiopathic acute vestibular dysfunction (vestibular neuritis).用于治疗特发性急性前庭功能障碍(前庭神经炎)的皮质类固醇
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Pharmacotherapy of vestibular and ocular motor disorders, including nystagmus.前庭和眼动障碍的药物治疗,包括眼球震颤。
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Vestibular rehabilitation for unilateral peripheral vestibular dysfunction.单侧外周前庭功能障碍的前庭康复治疗
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The therapeutic mode of action of 4-aminopyridine in cerebellar ataxia.4-氨基吡啶治疗小脑共济失调的作用模式。
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HINTS to diagnose stroke in the acute vestibular syndrome: three-step bedside oculomotor examination more sensitive than early MRI diffusion-weighted imaging.急性前庭综合征中诊断卒中的HINTS:三步床边动眼神经检查比早期MRI弥散加权成像更敏感
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