Department of Otolaryngology, Saint Louis University School of Medicine, St Louis, Missouri, USA.
Laryngoscope. 2013 May;123(5):1289-93. doi: 10.1002/lary.23844. Epub 2013 Jan 3.
OBJECTIVES/HYPOTHESIS: To study the correlation between obstructive sleep apnea (OSA), obesity, behavior, and quality of life.
Case-control study of pediatric OSA documented by polysomnography at a tertiary-care hospital.
Caregivers signed a consent document and completed the Behavior Assessment System for Children (BASC-2) and the 18-item OSA Quality-of-Life Survey (OSA-18) questionnaires. Demographic and polysomnographic data were collected. Children were classified as obese with OSA, normal weight with OSA, or primary snoring ([PS] normal weight, sleep-disordered breathing, no OSA). The correlation between OSA severity and the degree of obesity as well as behavior and quality of life were compared among the three groups. A P value ≤.05 was considered significant.
Seventy-three patients were included in the study. Thirty-five children were obese with OSA (48%), 21 were of normal weight with OSA (29%), and 17 were considered PS (23%). There was no linear correlation between the degree of obesity and OSA severity. Apnea/hypopnea index was significantly higher for OSA-obese versus OSA-normal weight children (20.0 vs. 9.0, P = .02). The OSA-18 total score and BASC-2 mean score was worse for the OSA-obese than the OSA-normal group (P = .01 for both). There was no difference in quality-of-life scores or behavioral scores between the OSA-normal and PS groups.
The degree of obesity does not linearly predict OSA severity in children. Obese children have worse OSA, behavioral problems, and quality of life than normal-weight children. In normal-weight children with OSA or PS, behavior and quality-of-life scores are similar regardless of the severity of the sleep disorder.
3b.
目的/假设：研究阻塞性睡眠呼吸暂停（OSA）、肥胖、行为和生活质量之间的相关性。
在一家三级保健医院进行多导睡眠图记录的小儿 OSA 的病例对照研究。
护理人员签署同意书并完成行为评估系统儿童版（BASC-2）和 18 项 OSA 生活质量调查（OSA-18）问卷。收集人口统计学和多导睡眠图数据。将儿童分为 OSA 肥胖、正常体重伴 OSA 和单纯打鼾（PS 正常体重、睡眠呼吸障碍、无 OSA）。比较三组间 OSA 严重程度与肥胖程度以及行为和生活质量的相关性。P 值≤.05 被认为具有统计学意义。
本研究共纳入 73 例患者。35 例儿童为 OSA 肥胖（48%），21 例为 OSA 正常体重（29%），17 例为 PS（23%）。肥胖程度与 OSA 严重程度无线性相关。与 OSA 正常体重儿童相比，OSA 肥胖儿童的呼吸暂停/低通气指数显著更高（20.0 比 9.0，P =.02）。OSA-18 总分和 BASC-2 平均分在 OSA 肥胖组比 OSA 正常组更差（均为 P =.01）。OSA 正常组和 PS 组之间的生活质量评分或行为评分无差异。
肥胖程度不能线性预测儿童 OSA 的严重程度。肥胖儿童的 OSA、行为问题和生活质量比正常体重儿童更差。在伴有 OSA 或 PS 的正常体重儿童中，无论睡眠障碍的严重程度如何，行为和生活质量评分相似。
3b。
