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[腔内经导管电灼术作为难治性室性心动过速的一种治疗选择]

[Endocavitary transcatheter electric fulguration as a therapeutic alternative in refractory ventricular tachycardia].

作者信息

Santini M, Ansalone G, Cacciatore G, Di Marcotullio G, Carelli M, Tubaro M, Alexidou G, Bisceglie I

机构信息

Servizio di Elettrofisiologia ed Elettrostimolazione Cardiaca, Ospedale, San Camillo, Roma.

出版信息

G Ital Cardiol. 1990 Feb;20(2):96-105.

PMID:2328876
Abstract

Three patients affected by dilated cardiomyopathy complicated by refractory ventricular tachycardia, with a high risk of sudden cardiac death, underwent transcatheter electric fulguration. The technique was applied transeptally, using the terminals of two catheter electrodes as cathode and anode. These were placed at the right and left ventricular apex, at septal level where the "critical" arrhythmia point had been identified by endocardial mapping. All patients had previously experienced more than one episode of cardiac arrest and had successfully taken several antiarrhythmic drugs. All patients presented variable morphology of ventricular tachycardia (whether spontaneous or induced). In all of them clinical tachycardia was considered as having a left bundle branch block morphology with an earlier activation at low septal level. After treatment, antiarrhythmic therapy (amiodarone 200 mg/day) was continued for all patients, although at a lower dose than before fulguration. One patient has been free from sustained ventricular tachycardia for more than two years after fulguration. In the other patients we observed an early and late arrhythmic recurrence (respectively within 1 and 8 months following fulguration) in spite of antiarrhythmic therapy. The second patient presented no further recurrence after permanent pacemaker implantation. The third patient showed an arrhythmic recurrence, with a different morphology from the previous one, concomitantly with a septic process. This technique does not appear dangerous and may be used, in highly specialized centres, on carefully selected patients as a therapeutic approach after pharmacological therapy and before automatic defibrillator implantation or surgical antiarrhythmic intervention.

摘要

三名患有扩张型心肌病并伴有难治性室性心动过速、具有心脏性猝死高风险的患者接受了经导管电灼术。该技术经房间隔应用,使用两个导管电极的末端分别作为阴极和阳极。电极置于右心室和左心室心尖处,在室间隔水平,此处通过心内膜标测已确定“关键”心律失常点。所有患者此前均经历过不止一次心脏骤停,且已成功服用多种抗心律失常药物。所有患者的室性心动过速形态各异(无论是自发的还是诱发的)。他们所有人的临床心动过速均被认为具有左束支传导阻滞形态,且在低位室间隔水平有较早的激动。治疗后,所有患者继续接受抗心律失常治疗(胺碘酮200毫克/天),尽管剂量低于电灼术前。一名患者在电灼术后两年多未再发生持续性室性心动过速。在其他患者中,尽管接受了抗心律失常治疗,但我们观察到心律失常早期和晚期复发(分别在电灼术后1个月和8个月内)。第二名患者在植入永久性起搏器后未再复发。第三名患者出现心律失常复发,形态与之前不同,同时伴有脓毒症过程。该技术似乎并无危险,在高度专业化的中心,对于经过精心挑选的患者,可在药物治疗后、自动除颤器植入或手术性抗心律失常干预之前作为一种治疗方法使用。

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