Klein H, Frank G, Werner P C, Borst H G, Lichtlen P R
Herz. 1984 Apr;9(2):90-101.
Medical therapy for recurrent sustained ventricular tachycardia is often disappointing. We report on the direct i.e. electrophysiologically guided surgical approach to 44 patients with sustained ventricular tachycardia. 43 patients had previous myocardial infarction, one patient had arrhythmogenic right ventricular dysplasia. During preoperative electrophysiologic study, sustained ventricular tachycardia was induced in 41 patients, three patients had an incessant sustained ventricular tachycardia. 30 patients underwent endocardial catheter mapping. In 28 of 30 cases, the earliest endocardial activation during ventricular tachycardia was detected. Intraoperative mapping was performed in 42 patients, in two cases surgical approach was guided by the result of endocardial catheter mapping. In 34 patients endocardial mapping revealed the earliest site of ventricular tachycardia, in eight patients the arrhythmogenic area was identified by mapping during sinus rhythm. An encircling endocardial ventriculotomy was performed in 14 patients, whereas 29 patients underwent a circumscribed endocardial resection. A cryosurgical technique was performed in the patient with arrhythmogenic right ventricular dysplasia. The hospital mortality rate was 16% (seven of 42 patients), in one patient the cause of death was ventricular fibrillation. The late mortality rate is 14% (five of 37 patients), one patient had sudden cardiac death. Two patients had a recurrence of ventricular tachycardia postoperatively. In one of these an antitachycardia pacemaker was implanted, the other was successfully reoperated with endocardial resection. Postoperatively, a sustained ventricular tachycardia was inducible by programmed stimulation in three patients. Complex ventricular ectopic activity was found in ten patients, all of these were administered antiarrhythmic drugs. With respect to the poor prognosis of medically refractory ventricular tachycardia, we conclude that the electrophysiologically guided surgical approach has become an acceptable therapeutical alternative.
复发性持续性室性心动过速的药物治疗效果常常令人失望。我们报告了对44例持续性室性心动过速患者采用直接即电生理引导的手术方法。43例患者曾有心肌梗死,1例患者患有致心律失常性右心室发育不良。在术前电生理研究中,41例患者诱发了持续性室性心动过速,3例患者有持续性不间断室性心动过速。30例患者接受了心内膜导管标测。在30例中的28例中,检测到室性心动过速期间最早的心内膜激动。42例患者进行了术中标测,2例手术方法由心内膜导管标测结果引导。34例患者的心内膜标测显示了室性心动过速的最早部位,8例患者通过窦性心律期间的标测确定了致心律失常区域。14例患者进行了心内膜环行心室切开术,而29例患者接受了局限性心内膜切除术。对患有致心律失常性右心室发育不良的患者采用了冷冻手术技术。医院死亡率为16%(42例患者中的7例),1例患者死于心室颤动。晚期死亡率为14%(37例患者中的5例),1例患者发生心脏性猝死。2例患者术后室性心动过速复发。其中1例植入了抗心动过速起搏器,另1例通过心内膜切除术成功再次手术。术后,3例患者通过程序刺激可诱发持续性室性心动过速。10例患者发现有复杂的室性异位活动,所有这些患者均给予了抗心律失常药物。鉴于药物难治性室性心动过速预后较差,我们得出结论,电生理引导的手术方法已成为一种可接受的治疗选择。