Kwon A H, Inada Y, Uetsuji S, Yamamura M, Hioki K, Yamamoto M
Department of Surgery, Kansai Medical University, Osaka, Japan.
Hepatology. 1990 Apr;11(4):593-8. doi: 10.1002/hep.1840110411.
The relationship between plasma fibronectin concentration and the regenerative process in liver remnants after hepatectomy was studied in 12 patients and in male Sprague-Dawley rats with and without cirrhosis. Plasma fibronectin levels were reduced immediately after hepatectomy in humans and rats. Patients and rats without cirrhosis displayed preoperative fibronectin levels within 1 mo and 1 wk, respectively, but low fibronectin levels persisted longer in those with cirrhosis. Plasma fibronectin levels correlated well with the degree of hepatic regeneration in the patients with cirrhosis (r = 0.4227; p less than 0.05) and without cirrhosis (r = 0.8148; p less than 0.001), and also with the percentage of change in liver weight during regeneration in the rat with thioacetamide-induced cirrhosis (r = 0.4905; p less than 0.01) or in the rat without cirrhosis (r = 0.6422; p less than 0.001). These results suggest that plasma fibronectin is a useful marker for the detection of regenerating liver.
在12例患者以及雄性斯普拉格-道利大鼠（有无肝硬化）中研究了肝切除术后肝残余组织中血浆纤维连接蛋白浓度与再生过程之间的关系。人类和大鼠肝切除术后血浆纤维连接蛋白水平立即降低。无肝硬化的患者和大鼠术前纤维连接蛋白水平分别在1个月和1周内恢复，但肝硬化患者的低纤维连接蛋白水平持续时间更长。血浆纤维连接蛋白水平与肝硬化患者（r = 0.4227；p < 0.05）和无肝硬化患者（r = 0.8148；p < 0.001）的肝再生程度密切相关，也与硫代乙酰胺诱导肝硬化大鼠（r = 0.4905；p < 0.01）或无肝硬化大鼠（r = 0.6422；p < 0.001）再生期间肝脏重量变化的百分比密切相关。这些结果表明，血浆纤维连接蛋白是检测再生肝脏的有用标志物。
