Howard Hughes Medical Institute at Massachusetts General Hospital Cancer Center and Center for Regenerative Medicine, Boston, MA 02114, USA.
Cell Stem Cell. 2013 Jan 3;12(1):15-30. doi: 10.1016/j.stem.2012.12.007.
Sox family transcription factors are well-established regulators of cell fate decisions during development. Accumulating evidence documents that they play additional roles in adult tissue homeostasis and regeneration. Remarkably, forced expression of Sox factors, in combination with other synergistic factors, reprograms differentiated cells into somatic or pluripotent stem cells. Dysregulation of Sox factors has been further implicated in diseases including cancer. Here, we review molecular and functional evidence linking Sox proteins with stem cell biology, cellular reprogramming, and disease with an emphasis on Sox2.
Sox 家族转录因子是发育过程中细胞命运决定的重要调节因子。越来越多的证据表明，它们在成人组织稳态和再生中发挥额外的作用。值得注意的是，Sox 因子的强制表达，与其他协同因子结合，可将分化细胞重新编程为体干细胞或多能干细胞。Sox 因子的失调与包括癌症在内的疾病有关。在这里，我们回顾了 Sox 蛋白与干细胞生物学、细胞重编程和疾病的分子和功能证据，重点介绍 Sox2。
