Liu Yu, Guo Wenjun
Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Albert Einstein Cancer Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Semin Cell Dev Biol. 2021 Jun;114:126-133. doi: 10.1016/j.semcdb.2021.01.002. Epub 2021 Feb 12.
Emerging evidence has shown that several SOX family transcription factors are key regulators of stem/progenitor cell fates in the mammary gland. These cell-fate regulators are often upregulated in breast cancer and contribute to tumor initiation and progression. They induce lineage plasticity and the epithelial-mesenchymal transition, which promotes tumor invasion, metastasis, and therapeutic resistance. SOX factors act through modulating multiple oncogenic signaling pathways in breast cancer. In addition to the cell-autonomous functions, new evidence suggests they can shape the tumor immune microenvironment. Here, we will review the molecular and functional evidence linking SOX factors with mammary gland development and discuss how these cell-fate regulators are co-opted in breast cancer.
新出现的证据表明，几种SOX家族转录因子是乳腺中干细胞/祖细胞命运的关键调节因子。这些细胞命运调节因子在乳腺癌中常常上调，并促进肿瘤的起始和进展。它们诱导谱系可塑性和上皮-间质转化，从而促进肿瘤侵袭、转移和治疗抗性。SOX因子通过调节乳腺癌中的多种致癌信号通路发挥作用。除了细胞自主功能外，新证据表明它们还可以塑造肿瘤免疫微环境。在这里，我们将综述将SOX因子与乳腺发育联系起来的分子和功能证据，并讨论这些细胞命运调节因子在乳腺癌中是如何被利用的。
