Bruin P, Jonkman M F, Meijer H J, Pennings A J
Department of Polymer Chemistry, University of Groningen, The Netherlands.
J Biomed Mater Res. 1990 Feb;24(2):217-26. doi: 10.1002/jbm.820240208.
A polyetherurethane (PEU) wound covering with non-interconnected micropores up to approximately 5 microns has been prepared by means of a phase inversion process. This highly elastic, very thin (15-20 microns), pliable wound covering showed good, immediate adherence to wet wound surfaces and high water vapor permeability, but was impermeable to bacteria. In guinea pigs epidermal wound healing of partial-thickness wounds under PEU wound coverings was accelerated compared with uncovered controls and an occlusive wound covering, OpSite. Water in liquid form or wound exudate could not leak through the PEU covering, but its high water vapor permeability induced concentration of the wound exudate into a jellylike clot layer, which apparently accelerated reepithelialization. The main conclusion from a clinical study on 20 donor sites was that the use of the PEU covering reduced pain, besides prevention of fluid retention. No differences in epithelialization were seen in comparison to tulle gras-treated wounds.
通过相转化工艺制备了一种聚醚聚氨酯（PEU）伤口覆盖物，其具有高达约5微米的非相互连接的微孔。这种高弹性、非常薄（15 - 20微米）、柔韧的伤口覆盖物对湿润的伤口表面表现出良好的即时粘附性和高水蒸气渗透性，但对细菌不可渗透。与未覆盖的对照和封闭性伤口覆盖物OpSite相比，豚鼠在PEU伤口覆盖物下部分厚度伤口的表皮伤口愈合加速。液态水或伤口渗出液不会透过PEU覆盖物，但它的高水蒸气渗透性会使伤口渗出液浓缩成凝胶状凝块层，这显然加速了上皮再形成。对20个供皮区的临床研究得出的主要结论是，使用PEU覆盖物除了预防液体潴留外，还减轻了疼痛。与用凡士林纱布处理的伤口相比，上皮形成没有差异。
