Jonkman M F, Bruin P, Hoeksma E A, Nieuwenhuis P, Klasen H J, Pennings A J, Molenaar I
Centre for Medical Electron Microscopy, University of Groningen, The Netherlands.
Surgery. 1988 Sep;104(3):537-45.
Although the use of an occlusive wound covering accelerates the reepithelialization of a partial-thickness wound, it has the disadvantage of leading to wound exudate accumulation. The effect of an experimental polyetherurethane (PEU) wound covering with a high vapor permeability was compared with an occlusive wound covering (OpSite covering) and air exposure with respect to the rate of reepithelialization, eventual epidermal thickness, and scab thickness in 122 partial-thickness wounds in guinea pigs. The percentage of reepithelialization on day 2 was 85% in wounds covered with the permeable PEU membrane, whereas it was 66% and 35%, respectively, in wounds covered with the occlusive covering or exposed to air. The epidermal thickness did not differ among the three types of treatment. The scab thickness, however, was maximal in the uncovered air-exposed wounds. We conclude that epidermal wound healing is accelerated when the PEU wound covering is used. This wound-healing-promotion effect is apparently due to the high water vapor permeability of PEU, which induces clotting of the wound exudate, and subsequent jellifying of the clot layer.
尽管使用封闭性伤口覆盖物可加速部分厚度伤口的再上皮化，但它有导致伤口渗出液积聚的缺点。将具有高蒸汽渗透性的实验性聚醚聚氨酯（PEU）伤口覆盖物与封闭性伤口覆盖物（OpSite覆盖物）及暴露于空气中的情况相比较，观察其对豚鼠122处部分厚度伤口的再上皮化速率、最终表皮厚度和痂厚度的影响。在第2天，用可渗透PEU膜覆盖的伤口再上皮化百分比为85%，而用封闭性覆盖物覆盖或暴露于空气中的伤口分别为66%和35%。三种治疗方式的表皮厚度没有差异。然而，痂厚度在未覆盖且暴露于空气中的伤口中最大。我们得出结论，使用PEU伤口覆盖物时表皮伤口愈合会加速。这种促进伤口愈合的效果显然归因于PEU的高水蒸气渗透性，它可诱导伤口渗出液凝结，随后使凝块层胶凝。
