Down P F, Polak A, Regan R J
Postgrad Med J. 1979 Dec;55(654):897-902. doi: 10.1136/pgmj.55.650.897.
Acute massive vitamin D overdosage occurred in a family after eating food cooked in a nut oil containing 5 million units of vitamin D3/ml. The plasma vitamin D was 55 and 60 i.u./ml in the father and mother respectively, and 9.6 i.u./ml in their 11-month-old infant (normal range, 0--1.6 i.u/ml). All the family presented with symptoms of hypercalcaemia and the infant responded quickly to prednisone. After steroids had failed to control the hypercalcaemia in the parents, neutral phosphate was successful, although necessary for 9 months. Before phosphate therapy it was shown that both parents were in strongly negative calcium balance, indicating that the vitamin D was mobilizing calcium from bone. Eleven years later all 3 patients are well but a renal biopsy in one of them shows persistent nephrocalcinosis.
一个家庭在食用了用每毫升含500万单位维生素D3的坚果油烹饪的食物后发生了急性大量维生素D过量。父亲和母亲的血浆维生素D分别为55和60国际单位/毫升，他们11个月大的婴儿为9.6国际单位/毫升（正常范围为0 - 1.6国际单位/毫升）。全家人都出现了高钙血症症状，婴儿对泼尼松反应迅速。在类固醇未能控制父母的高钙血症后，中性磷酸盐治疗取得了成功，尽管需要持续9个月。在磷酸盐治疗前显示，父母双方的钙平衡均为强负平衡，表明维生素D正在从骨骼中动员钙。11年后，所有3名患者情况良好，但其中一人的肾活检显示存在持续性肾钙质沉着症。
