Wagner Carol L, Taylor Sarah N, Hollis Bruce W
Department of Pediatrics, Pediatric Nutritional Research Center, Darby Children's Research Institute, Medical University of South Carolina, Charleston, South Carolina 29425, USA.
Breastfeed Med. 2008 Dec;3(4):239-50. doi: 10.1089/bfm.2008.9984.
Abstract Vitamin D has emerged from obscurity, and its effects on various organ systems throughout the body down to the cellular level are being discovered. What was once thought to be a simple hormone affecting only bone and calcium metabolism has shifted. We no longer see vitamin D as a "vitamin" important only in childhood, but as a complex hormone that is involved not only in calcium homeostasis but also in the integrity of the innate immune system. Vitamin D deficiency is linked to inflammatory and long-latency diseases such as multiple sclerosis, rheumatoid arthritis, tuberculosis, diabetes, and various cancers, to name a few. In this review, we trace how we came to view vitamin D and how that view led to one of the largest epidemics of nutrient deficiency beginning in the late 20(th) century. We then discuss the needs of vitamin D in the context of the breastfeeding mother and her infant and child, why breastfed infants are particularly at risk, and what to do about it.
摘要 维生素D已从默默无闻中崭露头角，其对全身各个器官系统直至细胞水平的影响正在被发现。曾经被认为只是一种仅影响骨骼和钙代谢的简单激素的观念已经转变。我们不再将维生素D仅仅视为一种仅在儿童期重要的“维生素”，而是视为一种复杂的激素，它不仅参与钙稳态，还关乎先天免疫系统的完整性。维生素D缺乏与多种炎症性和潜伏期长的疾病相关，如多发性硬化症、类风湿性关节炎、结核病、糖尿病以及各种癌症等等。在本综述中，我们追溯了我们如何开始看待维生素D，以及这种观念如何导致了始于20世纪后期的最大规模的营养素缺乏流行之一。然后，我们在母乳喂养的母亲及其婴幼儿的背景下讨论维生素D的需求，母乳喂养的婴儿为何特别容易面临风险，以及对此应如何应对。
