Curso de Farmácia, Universidade do Oeste de Santa Catarina, Videira, SC 89560-000, Brazil.
Eur J Med Chem. 2013 Feb;60:233-9. doi: 10.1016/j.ejmech.2012.10.056. Epub 2012 Nov 30.
The current review presents the antitumoral properties of gallic acid and its ester derivatives. Numerous studies have indicated that the alkyl esters are more effective against tumor cell lines than gallic acid, and that this activity is related to their hydrophobic moiety. All related studies have shown that the antitumor activity is interconnected to the induction of apoptosis by different mechanisms and it depends on the cell type. The results presented in this review may help to emphasize that these compounds could be promising as a new alternative for the treatment of cancer, either alone or in combination with other antitumor drugs to potentiate their effects.
本综述介绍了没食子酸及其酯衍生物的抗肿瘤特性。大量研究表明，烷基酯比没食子酸对肿瘤细胞系更有效，这种活性与其疏水性部分有关。所有相关研究都表明，抗肿瘤活性与不同机制诱导的细胞凋亡有关，并且取决于细胞类型。本综述中呈现的结果可能有助于强调这些化合物具有作为癌症治疗新选择的潜力，无论是单独使用还是与其他抗肿瘤药物联合使用以增强其效果。
