Zhao Xinyi, Wang Xueni, Pang Yuzhou
Guangxi Zhuang Yao Medicine Center of Engineering and Technology, Guangxi University of Chinese Medicine, Nanning 530200, China.
CAS Key Laboratory of Tropical Marine Bio-Resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China.
Pharmaceuticals (Basel). 2022 Nov 5;15(11):1360. doi: 10.3390/ph15111360.
Ferroptosis, a recently discovered iron-dependent regulated cell death, has been implicated in the therapeutic responses of various cancers including breast cancer, making it a promising therapeutic target to manage this malignancy. Phytochemicals are conventional sources for medication development. Some phytochemicals have been utilized therapeutically to treat cancers as pharmaceutic agents or dietary supplements. Intriguingly, a considerable number of antitumor drugs derived from phytochemicals have been proven to be targeting ferroptosis, thus producing anticancer effects. In this review, we provide a short overview of the interaction between core ferroptosis modulators and breast cancer, illustrating how ferroptosis affects the destiny of breast cancer cells. We also systematically summarize the regulatory effects of phytochemicals on ferroptosis and emphasize their clinical applications in breast cancer suppression, which may accelerate the development of their therapeutic use in breast cancer.
铁死亡是一种最近发现的铁依赖性调节性细胞死亡，已被证明与包括乳腺癌在内的各种癌症的治疗反应有关，使其成为治疗这种恶性肿瘤的一个有前景的治疗靶点。植物化学物质是药物开发的传统来源。一些植物化学物质已被用作治疗癌症的药物或膳食补充剂。有趣的是，大量源自植物化学物质的抗肿瘤药物已被证明靶向铁死亡，从而产生抗癌作用。在这篇综述中，我们简要概述了核心铁死亡调节因子与乳腺癌之间的相互作用，阐明了铁死亡如何影响乳腺癌细胞的命运。我们还系统地总结了植物化学物质对铁死亡的调节作用，并强调了它们在抑制乳腺癌方面的临床应用，这可能会加速它们在乳腺癌治疗中的应用开发。
