Department of Rheumatology, Royal National Hospital for Rheumatic Diseases, Bath, UK.
Ann Rheum Dis. 2013 Aug;72(8):1358-61. doi: 10.1136/annrheumdis-2012-202608. Epub 2013 Jan 3.
To identify predictors of poorer physical function in established psoriatic arthritis (PsA).
PsA patients with disease duration of ≥10 years were identified from the Bath longitudinal cohort. Physical function was assessed using the Stanford Health Assessment Questionnaire (HAQ). Sex, age at diagnosis, duration of symptoms prior to diagnosis, smoking, treatment and year of diagnosis were included in a multivariable regression analysis to identify associations with HAQ.
267 patients were identified for inclusion. The median age was 56 years (IQR 45-63), median disease duration was 13 years (IQR 10-18) and median HAQ score was 0.63 (IQR 0.13-1.25). The model predicted significant increases in HAQ related to smoking (0.23, 95% CI 0.04 to 0.42), age >50 years at diagnosis (0.27, 95% CI 0.03 to 0.51), symptom duration of ≥1 year before diagnosis (0.22, 95% CI 0.02 to 0.42), female sex (0.39, 95% CI 0.20 to 0.57) and history of treatment with an anti-TNF agent (0.63, 95% CI 0.32 to 0.93) at follow-up.
Smoking, delay to diagnosis, older age at diagnosis, female sex and a history of anti-TNF treatment are associated with worse physical function in established PsA.
确定已确诊的银屑病关节炎（PsA）患者身体功能较差的预测因素。
从巴斯纵向队列中确定疾病病程≥10 年的 PsA 患者。使用斯坦福健康评估问卷（HAQ）评估身体功能。将性别、诊断时年龄、诊断前症状持续时间、吸烟、治疗和诊断年份纳入多变量回归分析，以确定与 HAQ 的关联。
确定了 267 名符合条件的患者。中位年龄为 56 岁（IQR 45-63），中位疾病病程为 13 年（IQR 10-18），中位 HAQ 评分为 0.63（IQR 0.13-1.25）。该模型预测与吸烟（0.23，95%CI 0.04 至 0.42）、诊断时年龄>50 岁（0.27，95%CI 0.03 至 0.51）、诊断前症状持续时间≥1 年（0.22，95%CI 0.02 至 0.42）、女性（0.39，95%CI 0.20 至 0.57）和抗 TNF 药物治疗史（0.63，95%CI 0.32 至 0.93）相关的 HAQ 显著增加。
吸烟、诊断延迟、诊断时年龄较大、女性和抗 TNF 治疗史与已确诊的 PsA 患者身体功能较差有关。
