Minopoulou Ioanna, Fagni Filippo, Atzinger Armin, Albach Fredrik, Schett Georg, Krönke Gerhard, Kleyer Arnd, Simon David
Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Department of Internal Medicine 3, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen, Erlangen, Germany.
Curr Rheumatol Rep. 2025 Jan 10;27(1):13. doi: 10.1007/s11926-024-01174-5.
Psoriatic arthritis (PsA) is a complex heterogeneous inflammatory disease that affects about one-third of patients with psoriasis. PsA leads to significant physical impairment and reduced quality of life. Therefore, early diagnosis and intervention are critical for improving long-term outcomes. The purpose of this review is to highlight the advantages of unconventional imaging methods in the diagnosis and management of PsA and to discuss recent advancements in imaging technology.
Conventional imaging methods, such as radiography, musculoskeletal ultrasound, and magnetic resonance imaging, have been instrumental in detecting structural joint damage and inflammation. However, these imaging modalities have several limitations, resulting in their inability to detect early disease changes. Recent advancements in imaging technology have led to the development of novel imaging modalities capable of characterizing not only early structural but also molecular aspects of disease activity. These cutting-edge approaches have been lately applied to both psoriasis and PsA patients, offering new insights into disease progression, the transition from psoriasis to PsA, and treatment responses. By providing more detailed and individualized assessments, unconventional imaging modalities may bring us closer to realizing the potential of personalized medicine in the management of PsA.
银屑病关节炎（PsA）是一种复杂的异质性炎症性疾病，约三分之一的银屑病患者会受到影响。PsA会导致严重的身体功能障碍和生活质量下降。因此，早期诊断和干预对于改善长期预后至关重要。本综述的目的是强调非常规成像方法在PsA诊断和管理中的优势，并讨论成像技术的最新进展。
传统成像方法，如X线摄影、肌肉骨骼超声和磁共振成像，在检测关节结构损伤和炎症方面发挥了重要作用。然而，这些成像方式存在一些局限性，导致它们无法检测到疾病的早期变化。成像技术的最新进展促使了新型成像方式的发展，这些成像方式不仅能够表征疾病活动的早期结构变化，还能表征分子层面的变化。这些前沿方法最近已应用于银屑病和PsA患者，为疾病进展、从银屑病到PsA的转变以及治疗反应提供了新的见解。通过提供更详细和个性化的评估，非常规成像方式可能会使我们更接近在PsA管理中实现个性化医疗的潜力。
