Assmann B, Haas H J
Fachrichtung Physiologische Chemie, Universität des Saarlandes, Homburg/Saar, F.R.G.
J Chromatogr. 1990 Feb 23;525(2):277-85. doi: 10.1016/s0378-4347(00)83404-0.
Excretion rates of uracil and thymine in children (n = 140) and circadian rhythms of urinary uracil excretion (n = 9) were investigated by reversed-phase high-performance liquid chromatography with ultraviolet detection. Excretion values were related to urinary creatinine determined by Jaffé's method. Creatinine-related uracil excretion was not dependent on age or sex. The values seemed to be distributed according to a Gaussian graph in both school children and those in hospital. The intra-individual range was 1.32-23.70 mg uracil per g creatinine over a four-day period in one subject. Uracil excretion seems to be somewhat lower during the night.
采用反相高效液相色谱-紫外检测法研究了140名儿童尿嘧啶和胸腺嘧啶的排泄率以及9名儿童尿嘧啶排泄的昼夜节律。排泄值与用杰氏法测定的尿肌酐相关。与肌酐相关的尿嘧啶排泄不依赖于年龄或性别。在学龄儿童和住院儿童中，这些值似乎都呈高斯分布。在一名受试者的四天时间里，个体内尿嘧啶排泄范围为每克肌酐1.32 - 23.70毫克。尿嘧啶排泄在夜间似乎略低。
