Speek A J, Thissen J T, Schrijver J
J Clin Chem Clin Biochem. 1986 Jul;24(7):465-70. doi: 10.1515/cclm.1986.24.7.465.
The urinary excretion of 3-methylhistidine and creatinine and the urinary 3-methylhistidine to creatinine excretion ratio during day and night were investigated in a group of 103 healthy, normally fed Dutch children (52 boys and 51 girls) aged 2-17 years. The 3-methylhistidine to creatinine ratio of the night urine appeared to be significantly higher than that of the urine produced during the day, irrespective of sex and age. This difference was about 30%. For both sexes it was found that the 3-methylhistidine and creatinine excretion increased and that the 3-methylhistidine to creatinine ratio decreased with age. Although the creatinine excretion by boys was significantly higher than that by girls of the same age, no differences were seen between the sexes with respect to the 3-methylhistidine excretion or the 3-methylhistidine to creatinine ratio. A clear linear relation was found between the day or night urine and the 24 h urine with respect to the 3-methylhistidine to creatinine ratio. However, no such relation was observed between the day and the night urine. These results are discussed in relation to the use of smaller urine samples instead of 24 hour urine in the study of 3-methylhistidine excretion.
对103名年龄在2至17岁、健康且饮食正常的荷兰儿童（52名男孩和51名女孩）进行了研究，测定了他们白天和夜间尿中3-甲基组氨酸和肌酐的排泄量以及尿中3-甲基组氨酸与肌酐的排泄比值。无论性别和年龄，夜间尿中3-甲基组氨酸与肌酐的比值均显著高于白天产生的尿液，差异约为30%。对于男女两性，均发现3-甲基组氨酸和肌酐排泄量随年龄增加，而3-甲基组氨酸与肌酐的比值随年龄降低。虽然同龄男孩的肌酐排泄量显著高于女孩，但在3-甲基组氨酸排泄量或3-甲基组氨酸与肌酐的比值方面，两性之间未观察到差异。在3-甲基组氨酸与肌酐的比值方面，发现白天或夜间尿液与24小时尿液之间存在明显的线性关系。然而，在白天和夜间尿液之间未观察到这种关系。结合在研究3-甲基组氨酸排泄时使用较小尿液样本而非24小时尿液的情况，对这些结果进行了讨论。
