Miyata Jun, Tasaka Sadatomo, Miyazaki Masaki, Yoshida Syuichi, Naoki Katsuhiko, Sayama Koichi, Asano Koichiro, Fujiwara Hiroshi, Ohkusu Kiyofumi, Hasegawa Naoki, Betsuyaku Tomoko
Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Japan.
Intern Med. 2013;52(1):101-4. doi: 10.2169/internalmedicine.52.7282. Epub 2013 Jan 1.
Bacillus cereus (B. cereus) is a Gram-positive rod that is widely distributed in the environment and can be a cause of food poisoning. We herein present a case of B. cereus necrotizing pneumonia in a patient with nephrotic syndrome under corticosteroid treatment after developing transient gastroenteritis symptoms. B. cereus was isolated from bronchial lavage fluid and transbronchial biopsy specimens. A multiplex polymerase chain reaction analysis of the toxin genes revealed a strain possessing enterotoxicity. The patient recovered after one week of intravenous meropenem followed by a combination of oral moxifloxacin and clindamycin. B. cereus is a pathogen that causes necrotizing pneumonia in immunocompromised hosts.
蜡样芽孢杆菌是一种革兰氏阳性杆菌，广泛分布于环境中，可导致食物中毒。我们在此报告一例蜡样芽孢杆菌坏死性肺炎病例，患者为肾病综合征，在出现短暂性肠胃炎症状后接受皮质类固醇治疗。蜡样芽孢杆菌从支气管灌洗液和经支气管活检标本中分离出来。毒素基因的多重聚合酶链反应分析显示该菌株具有肠毒性。患者在静脉注射美罗培南一周后康复，随后口服莫西沙星和克林霉素联合治疗。蜡样芽孢杆菌是一种可在免疫功能低下宿主中引起坏死性肺炎的病原体。
