Sakamoto S, Shimizu T, Kaneto Y, Toyoda T
Department of Thoracic and Cardiovascular Surgery, Kanazawa Medical University, Ishikawa, Japan.
Nihon Kyobu Geka Gakkai Zasshi. 1990 Jan;38(1):116-20.
A 40-year-old female who had been treated with steroid for 10 years because of systemic lupus erythematosus (SLE) was admitted to our department for triple-vessel disease with LMT lesion. She underwent bilateral internal mammary artery grafting to the right ventricular branch of RCA and the No. 7 segment of LAD. Intraoperative free flow was 70 ml/min in both bypass grafts. She dropped to severe shock with a high fever of 40 degrees C and decreased the white blood cell count of 900/mm3 on the 6th postoperative day. These clinical and laboratory findings were suggestive of rebound phenomenon of SLE or withdrawal syndrome of steroid therapy. She was treated with pulse therapy of methyl-prednisolone and her condition improved in two weeks. Histological findings of the right internal mammary artery revealed stenotic lesion of about 50%, but on June 24, 1988, postoperative angiography showed a good patency of both internal mammary arteries. Only a few reports of successful attempt of coronary artery bypass grafting for coronary lesion due to SLE are available in the literature. Some important problems concerning the surgical treatment as well as the therapy of steroid involved in this case were discussed.
一名因系统性红斑狼疮(SLE)接受了10年类固醇治疗的40岁女性因右冠状动脉(RCA)病变伴三支血管病变入住我科。她接受了双侧胸廓内动脉移植至RCA右心室分支及左前降支(LAD)第7段。术中两个搭桥移植物的自由血流均为70 ml/min。术后第6天,她出现严重休克,体温高达40℃,白细胞计数降至900/mm³。这些临床和实验室检查结果提示SLE的反跳现象或类固醇治疗的撤药综合征。她接受了甲泼尼龙冲击治疗,两周后病情好转。右胸廓内动脉的组织学检查发现约50%的狭窄病变,但在1988年6月24日,术后血管造影显示两支胸廓内动脉通畅良好。文献中仅有少数关于因SLE导致冠状动脉病变成功进行冠状动脉搭桥术的报道。讨论了该病例中涉及的手术治疗以及类固醇治疗的一些重要问题。