Wolfson Brain Imaging Centre, Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom.
J Magn Reson Imaging. 2013 Aug;38(2):468-73. doi: 10.1002/jmri.24001. Epub 2013 Jan 4.
To demonstrate and validate a late gadolinium enhancement (LGE) imaging protocol, optimized for tissue viability assessment in interventional mouse models of myocardial infarction.
The method uses an efficient sampling scheme using multiple slices in a single heartbeat interleaving slice packages between alternate TRs. Sampling multiple slices instead of multiple echoes or multiple k-lines achieves higher SNR efficiency, and images covering the whole heart can be obtained in 3 min. Saturation effects are exploited for an optimum compromise between contrast and speed.
The images obtained show high hyperenhancement with good contrast-to-noise. It is shown that inversion time optimization can be reliably omitted with this scheme, and that measured infarct sizes correlate well with histological measures.
Our protocol offers a new efficient tool for the measurement of infarct size in mouse models of heart disease.
展示和验证一种优化的钆延迟增强（LGE）成像方案，用于介入性心肌梗死小鼠模型中的组织活力评估。
该方法使用一种高效的采样方案，在单个心跳中交错切片包，在交替的 TR 之间插入多个切片。与使用多个回波或多个 k 线相比，采样多个切片可实现更高的 SNR 效率，并且可以在 3 分钟内获得覆盖整个心脏的图像。利用饱和效应可以在对比度和速度之间实现最佳折衷。
获得的图像显示出高的超强化，具有良好的对比度噪声比。结果表明，该方案可以可靠地省略反转时间优化，并且测量的梗死面积与组织学测量结果具有良好的相关性。
我们的方案为心脏病小鼠模型中梗死面积的测量提供了一种新的高效工具。
