University of Rosario Medical School, 2000 Rosario, Argentina.
Ann Hepatol. 2013 Jan-Feb;12(1):22-9.
Pharmacological therapy of portal hypertensión can be accomplished according to different objectives. Among them, pre-primary prophylaxis aims to avoid / delay esophageal varices development while the target of primary prophylaxis is protection against first variceal bleeding. Hepatic venous pressure gradient (HVPG) measurement closely reflects portal pressure in most liver diseases whith predominant sinusoidal network involvement. Clinical-hemodynamic correlations have been demonstrated in both pre-primary and primary prophylatic therapy, allowing to establish HVPG measurement as a predictive parameter, not only regarding variceal growth and bled but also of liver disease evolution and other portal hypertensive related complications.
门脉高压症的药物治疗可根据不同的目标来完成。其中，一级预防的目的是预防/延缓食管静脉曲张的发展，而二级预防的目标是防止首次静脉曲张出血。在大多数以窦状隙网络受累为主的肝脏疾病中，肝静脉压力梯度（HVPG）测量密切反映门静脉压力。在一级和二级预防性治疗中均已证明了临床-血流动力学的相关性，这使得 HVPG 测量成为一个预测参数，不仅与静脉曲张的生长和出血有关，而且与肝病的进展和其他门脉高压相关的并发症有关。
