Department of Medical Biochemistry, School of Medicine, Flinders University, Adelaide, South Australia 5001, Australia.
Ann Hepatol. 2013 Jan-Feb;12(1):130-7.
Female patients exhibit better survival and less hepatic damage from ischemia reperfusion (IR) injury following surgery. However, the effects of sex and estrogens on liver function in the acute phase of IR are not well understood. Objective. The aim was to investigate this question.
A rat model of segmental hepatic ischemia was employed. Rats were pre-treated with the estrogen receptor antagonist ICI182,780 and/or the estrogen receptor agonist 17β-estradiol. Bile flow, blood concentrations of bilirubin and liver enzymes were measured, and liver histology was assessed.
Bile flow recovery immediately after the initiation of reperfusion was faster in females than in males. ICI182,780 reduced the rate of bile flow recovery in females but this reduction was not reversed by co-administration of 17 β-estradiol. In males, 17 β-estradiol alone did not enhance bile flow recovery. The changes in bile flow recovery observed under a given condition were correlated with small changes in blood liver enzymes and liver histology.
Sex has a significant influence on the early recovery of liver function in the acute phase of IR injury. However, in female rats estrogen receptors play only a limited role in mediating enhanced recovery of liver function.
女性患者在手术后表现出更好的生存和更少的缺血再灌注（IR）损伤引起的肝损伤。然而，性别和雌激素对 IR 急性期肝功能的影响尚不清楚。目的。本研究旨在探讨这一问题。
采用大鼠肝段缺血模型。大鼠预先用雌激素受体拮抗剂 ICI182,780 和/或雌激素受体激动剂 17β-雌二醇预处理。测量胆汁流量、胆红素和肝酶的血液浓度，并评估肝组织学。
再灌注开始后，女性的胆汁流量恢复速度快于男性。ICI182,780 降低了女性的胆汁流量恢复速度，但这一降低并未被 17β-雌二醇共同给药逆转。在男性中，单独使用 17β-雌二醇并不能增强胆汁流量恢复。在给定条件下观察到的胆汁流量恢复变化与血液肝酶和肝组织学的微小变化相关。
性别对 IR 损伤急性期肝功能的早期恢复有显著影响。然而，在雌性大鼠中，雌激素受体在介导肝功能恢复增强方面仅起有限作用。
