IRCCS-AOU San Martino-IST, Largo Rosanna Benzi 10, 16132, Genoa- Italy.
Development. 2013 Feb 1;140(3):483-6. doi: 10.1242/dev.085852.
The discovery in the year 2000 that radial glial cells act as neural stem and progenitor cells in development has led to a change in the concept of neural stem cells in the adult brain. Not only are adult stem cells in the neurogenic niches glial in nature, but also glial cells outside these niches display greater potential when reacting to brain injury. Thus, a concept that emerged from developmental studies may hold the clue for neural repair.
2000 年的一项发现表明，放射状胶质细胞在发育过程中充当神经干细胞和祖细胞，这一发现改变了成年大脑中神经干细胞的概念。不仅神经发生龛中的成年干细胞本质上是神经胶质细胞，而且这些龛外的神经胶质细胞在对脑损伤作出反应时表现出更大的潜能。因此，这一源自发育研究的概念可能为神经修复提供了线索。
