Endo Shunji, Dousei Tsutomu, Yoshikawa Yukinobu, Hatanaka Nobutaka, Taniyama Kiyomi, Yamauchi Amane, Kamiike Wataru, Nishijima Junichi
1 Department of Surgery, Higashiosaka City General Hospital, Higashiosaka-shi, Osaka, Japan.
Int Surg. 2012 Oct-Dec;97(4):335-9. doi: 10.9738/CC134.1.
In 2010, World Health Organization classified gastric neuroendocrine tumor (NET) as follows: NET grade (G) 1, NET G2, neuroendocrine carcinoma (NEC). We reviewed 22 gastric NETs that were encountered in our institutions. Nine, 6, and 4 were NET G1, G2, and NEC, respectively. We also encountered 3 NET G3. NET G1 was treated with observation in 2 patients, endoscopic mucosal resection (EMR) in 3, and gastrectomy in 4 patients. No recurrence was experienced during a median of 53 months of follow-up. All NET G2 was treated with gastrectomy. No patient experienced recurrence during a median of 25 months of follow-up. NET G3 was treated with gastrectomy. One patient died of liver metastasis 52 months after gastrectomy. For NEC, gastrectomy was performed in 3 cases and no patients died of tumor-related death. We conclude that the prognoses of NET G1 and G2 were good. We also experienced long-term survivors of NEC. An accumulation of more patients is needed for further investigation.
2010年，世界卫生组织将胃神经内分泌肿瘤（NET）分类如下：NET 1级（G1）、NET G2、神经内分泌癌（NEC）。我们回顾了在我们机构遇到的22例胃NET。其中分别有9例、6例和4例为NET G1、G2和NEC。我们还遇到了3例NET G3。2例NET G1患者接受观察治疗，3例接受内镜黏膜切除术（EMR），4例接受胃切除术。在中位随访53个月期间无复发。所有NET G2均接受胃切除术治疗。在中位随访25个月期间无患者复发。NET G3接受胃切除术治疗。1例患者在胃切除术后52个月死于肝转移。对于NEC，3例患者接受了胃切除术，无患者死于肿瘤相关死亡。我们得出结论，NET G1和G2的预后良好。我们也有NEC的长期存活者。需要积累更多患者进行进一步研究。
