Nassereddine Hussein, Chicaud Matthieu, Rebah Khedidja, Théou-Anton Nathalie, Sautet Anne, Dermer Jacques, Couvelard Anne
Département de Pathologie, Hôpital Bichat, AP-HP, 46 Rue Henri Huchard, 75018, Paris, France.
Sorbonne Université, Paris, France.
Endocr Pathol. 2021 Dec;32(4):517-523. doi: 10.1007/s12022-021-09681-2. Epub 2021 May 21.
Gastric type 1 neuroendocrine tumours are considered to have low rates of proliferation and a good prognosis. We report here a patient with an aggressive well-differentiated high-grade gastric neuroendocrine tumour (gastric grade 3 NET), in a context of autoimmune gastritis. Consistent with grade 3 disease, the tumour had a Ki-67 proliferation index of 30%. Targeted next-generation sequencing identified variants of four genes, including a pathogenic ATM variant underlying the differentiation and metastatic potential of the tumour. Liver metastasis was diagnosed during follow-up, and the patient died after 6 years, due to disease progression.
胃1型神经内分泌肿瘤被认为增殖率低且预后良好。我们在此报告一名患有侵袭性高分化高级别胃神经内分泌肿瘤（胃3级神经内分泌肿瘤）的患者，其处于自身免疫性胃炎背景下。与3级疾病相符，该肿瘤的Ki-67增殖指数为30%。靶向二代测序鉴定出四个基因的变异，包括一个导致肿瘤分化和转移潜能的致病性ATM变异。随访期间诊断出肝转移，患者在6年后因疾病进展死亡。
