Lymphocyte ecto-5'-nucleotidase activity as a marker of B-cell maturation.

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作者信息

Boss G R, Thompson L F, Spiegelberg H L, Waldmann T A, O'Connor R D, Hamburger R N, Seegmiller J E

出版信息

Trans Assoc Am Physicians. 1979;92:309-15.

PMID:232944

Abstract

摘要

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Lymphocyte ecto-5'-nucleotidase activity as a marker of B-cell maturation.

Trans Assoc Am Physicians. 1979;92:309-15.

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Ecto-5'-nucleotidase expression during human B cell development. An explanation for the heterogeneity in B lymphocyte ecto-5'-nucleotidase activity in patients with hypogammaglobulinemia.人B细胞发育过程中的外切5'-核苷酸酶表达。对低丙种球蛋白血症患者B淋巴细胞外切5'-核苷酸酶活性异质性的一种解释。

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Distribution of ecto-5'-nucleotidase on subsets of human T and B lymphocytes as detected by indirect immunofluorescence using goat antibodies.使用山羊抗体通过间接免疫荧光检测人T和B淋巴细胞亚群上的胞外5'-核苷酸酶分布。

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Decreased T cell ecto-5'-nucleotidase activity in agammaglobulinemia patients is not due to altered proportions of helper and suppressor T cells as defined by the monoclonal antibodies OKT4 and OKT8.无丙种球蛋白血症患者T细胞外5'-核苷酸酶活性降低并非由于由单克隆抗体OKT4和OKT8所定义的辅助性T细胞和抑制性T细胞比例改变所致。

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An explanation for the heterogeneity in B lymphocyte ecto-5'-nucleotidase activity in patients with hypogammaglobulinemia.

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Ecto-5'-nucleotidase activity in human T cell subsets. Decreased numbers of ecto-5'-nucleotidase positive cells from both OKT4+ and OKT8+ cells in patients with hypogammaglobulinemia.人T细胞亚群中的外切5'-核苷酸酶活性。低丙种球蛋白血症患者中OKT4+和OKT8+细胞中外切5'-核苷酸酶阳性细胞数量减少。

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Synthesis of immunoglobulin G by pokeweed mitogen- or Epstein-Barr virus-stimulated human B cells in vitro is restricted to the ecto-5'-nucleotidase positive subset.体外经商陆有丝分裂原或爱泼斯坦-巴尔病毒刺激的人B细胞合成免疫球蛋白G仅限于ecto-5'-核苷酸酶阳性亚群。

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