Barra Gustavo Barcelos, Dutra Ludmila Alves Sanches, Watanabe Sílvia Conde, Costa Patrícia Godoy Garcia, Cruz Patrícia Sales Marques da, Azevedo Monalisa Ferreira, Amato Angélica Amorim
Instituto e Laboratório Sabin de Análises Clínicas, Unidade de Biologia Molecular, Brasília, DF, Brazil.
Arq Bras Endocrinol Metabol. 2012 Nov;56(8):479-84. doi: 10.1590/s0004-27302012000800003.
To investigate the association of the T allele of the single nucleotide polymorphism (SNP) rs7903146 of TCF7L2 with the occurrence of T2D in a sample of subjects followed up at the Brasilia University Hospital.
The SNP rs7903146 of TCF7L2 was genotyped by allele-specific PCR in 113 patients with known T2D and in 139 non-diabetic controls in Brasilia, Brazil.
We found that the T allele of the SNP rs7903146 of TCF7L2 was significantly associated with T2D risk (odds ratio of 3.92 for genotype TT in the recessive genetic model, p = 0.004 and 1.5 for T allele, p = 0.032).
These results reinforce previous findings on the consistent association of this genetic factor and the risk of T2D in populations of diverse ethnic backgrounds.
在巴西利亚大学医院随访的受试者样本中，研究转录因子7样蛋白2（TCF7L2）单核苷酸多态性（SNP）rs7903146的T等位基因与2型糖尿病（T2D）发生之间的关联。
采用等位基因特异性聚合酶链反应（PCR）对巴西巴西利亚113例已知T2D患者和139例非糖尿病对照者的TCF7L2基因SNP rs7903146进行基因分型。
我们发现，TCF7L2基因SNP rs7903146的T等位基因与T2D风险显著相关（隐性遗传模型中基因型TT的优势比为3.92，p = 0.004；T等位基因为1.5，p = 0.032）。
这些结果强化了先前的研究发现，即该遗传因素与不同种族背景人群中T2D风险之间存在一致关联。
