Department of Neurology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
Eur Neurol. 2013;69(3):179-84. doi: 10.1159/000342892. Epub 2012 Dec 29.
BACKGROUND/AIMS: Although previous studies showed a high prevalence of abnormal ankle-brachial index (ABI) in patients with ischemic stroke, few data exist regarding ABI in Asian patients with ischemic stroke. The purpose of the present study was to determine the prevalence and factors associated with abnormal ABI (≤0.9) in a cohort of ischemic stroke patients.
In this prospective multicenter study, 1,293 patients diagnosed with acute ischemic stroke or transient ischemic attack underwent ABI measurement to evaluate an association between abnormal ABI and vascular risk factors and clinical characteristics. Differences in ABI by stroke subtypes were also assessed.
Abnormal ABI of ≤0.9 was found in 13.0%. Patients with abnormal ABI were more likely to be older and had higher initial stroke severity. The prevalence of abnormal ABI was 18.4% in large artery atherosclerosis, 7% in small artery disease, and 19.2% in cardioembolism (p < 0.001). Multiple logistic regression analysis showed that age, hyperlipidemia, diabetes, and large artery atherosclerosis subtype were independent factors associated with abnormal ABI.
These data suggest that the prevalence of abnormal ABI in Korean patients with ischemic stroke was lower than that in Caucasian patients, which might be associated with ethnic differences in underlying stroke subtypes.
背景/目的：尽管先前的研究表明，缺血性脑卒中患者的踝臂指数（ABI）异常发生率较高，但关于亚洲缺血性脑卒中患者的 ABI 数据较少。本研究旨在确定缺血性脑卒中患者队列中 ABI 异常（≤0.9）的发生率及相关因素。
在这项前瞻性多中心研究中，对 1293 例急性缺血性脑卒中或短暂性脑缺血发作患者进行 ABI 测量，以评估 ABI 异常与血管危险因素和临床特征之间的关系。还评估了不同卒中亚型之间的 ABI 差异。
发现 ABI 异常（≤0.9）的比例为 13.0%。ABI 异常患者的年龄更大，初始卒中严重程度更高。大动脉粥样硬化型的 ABI 异常发生率为 18.4%，小动脉疾病型为 7%，心源性栓塞型为 19.2%（p<0.001）。多因素逻辑回归分析显示，年龄、血脂异常、糖尿病和大动脉粥样硬化型是与 ABI 异常相关的独立因素。
这些数据表明，韩国缺血性脑卒中患者的 ABI 异常发生率低于高加索患者，这可能与潜在卒中亚型的种族差异有关。
