Frattola L, Tonini C, Villani R, Trabucchi M
Acta Neurol Scand. 1979 Dec;60(6):344-51. doi: 10.1111/j.1600-0404.1979.tb07660.x.
Since the effects of cyclic nucleotides are mediated via protein kinases activation, we have studied the properties and regulation of these enzymes in cytosol and particulate fraction of normal cerebral tissues and of some human brain tumors. We found that distribution and activity of cyclic nucleotide-dependent protein kinases are regulated differently among various brain tumors and in comparison to normal gray and white matter. Pathological tissues show an higher cGMP-dependent protein kinase and this biochemical pattern is particularly evident in tumors with more pronounced malignancy. These data further confirm the hypothesis of a correlation between the increase of cGMP function and cellular growth and malignancy.
由于环核苷酸的作用是通过蛋白激酶激活介导的，我们研究了这些酶在正常脑组织和一些人脑肿瘤的胞浆和颗粒部分中的性质和调节。我们发现，环核苷酸依赖性蛋白激酶的分布和活性在各种脑肿瘤之间以及与正常灰质和白质相比存在不同的调节。病理组织显示出较高的cGMP依赖性蛋白激酶，这种生化模式在恶性程度更明显的肿瘤中尤为明显。这些数据进一步证实了cGMP功能增加与细胞生长和恶性肿瘤之间存在相关性的假设。
