Kawasaki M, Yamano Y, Kikuchi Y, Sata T, Harada M, Niho Y
Department of Internal Medicine, Kyushu Kosei Nenkin Hospital.
Rinsho Ketsueki. 1990 Feb;31(2):224-8.
A 28-year-old man was admitted to our hospital because of cardiac tamponade and pleural effusion. Although his peripheral blood picture was normal, his pericardial fluid contained a lot of myeloblasts with Auer bodies and a diagnosis of acute myeloblastic leukemia (M2) was made from the finding of bone marrow smears. The pericarditis was successfully treated with instillation of mitoxantrone into the pericardial space after drainage. He responded well to the systemic chemotherapy and achieved a complete remission. Although 27 cases of leukemia complicated with cardiac tamponade have so far reported, only three cases gave normal findings of the peripheral blood on admission. Leukemic pericardial effusion with cardiac tamponade in very rare as an initial manifestation of AML. The efficacy and safety of pericardial infusion of mitoxantrone were demonstrated in this patient.
一名28岁男性因心脏压塞和胸腔积液入院。尽管其外周血象正常，但其心包积液中含有大量带有奥氏小体的成髓细胞，根据骨髓涂片检查结果诊断为急性髓细胞白血病（M2型）。心包引流后向心包腔内注入米托蒽醌，心包炎得到成功治疗。他对全身化疗反应良好，实现了完全缓解。尽管迄今为止已报道27例白血病合并心脏压塞的病例，但仅有3例入院时外周血检查结果正常。白血病性心包积液伴心脏压塞作为急性髓细胞白血病的初始表现非常罕见。该患者显示了心包注入米托蒽醌的有效性和安全性。
