脑血管阻塞性疾病：使用动态磁敏感对比 MRI 测量的定量脑血流与定量 H2[15O] PET 相关。
Cerebrovascular occlusive disease: quantitative cerebral blood flow using dynamic susceptibility contrast mr imaging correlates with quantitative H2[15O] PET.
机构信息
Department of Biomedical Engineering and Feinberg School of Medicine, Northwestern University, 737 N Michigan Ave, Suite 1600, Chicago, IL 60611, USA.
出版信息
Radiology. 2013 Mar;266(3):879-86. doi: 10.1148/radiol.12120756. Epub 2013 Jan 7.
PURPOSE
To compare quantitative values of cerebral blood flow (CBF) derived from dynamic susceptibility contrast (DSC) magnetic resonance (MR) imaging with reference standard positron emission tomography (PET) in patients with confirmed cerebrovascular occlusive disease.
MATERIALS AND METHODS
Local institutional review board approval and informed consent were obtained for a prospective study of 18 patients (six men, 12 women; age range, 28-71 years; mean age, 45 years ± 10.4 [standard deviation]) with angiographically confirmed Moyamoya (n = 8) or internal carotid artery occlusions (n = 10). DSC MR images and oxygen 15-labeled water (H(2)[(15)O]) PET images were acquired on the same day. DSC images were postprocessed to yield parametric images of CBF (in mL/100 g/min), coregistered, and analyzed using grid-based regions of interest. Mean values of CBF in each region of interest from MR imaging and PET data sets were compared. Correlations for each patient were determined and overall agreement between pooled MR imaging and PET CBF was reported using linear regression analysis and Bland-Altman plots.
RESULTS
Strong correlations (r(2) ≥ 0.55) were found between MR imaging and PET CBF values in all patients. Use of the bookend approach was found to underestimate CBF predictably across the patient cohort (mean slope, 0.82; standard deviation, 0.18; slope of aggregated data, 0.75). This allowed for a simple rescaling of MR imaging values producing strong agreement with PET values in the aggregated data (r(2) = 0.66; slope = 1.00; intercept = 0.00).
CONCLUSION
The data show that the bookend MR imaging technique produces similar results for quantitative CBF between DSC MR imaging and H(2)[(15)O] PET. Although MR-derived CBF underestimated PET-derived CBF, the patient-to-patient variability in the slopes of the linear MR and PET relationships was significantly smaller than a competing quantitation technique. As a result, the bookend technique appears to more predictably measure quantitative CBF in a clinical setting.
目的
比较经动态磁敏感对比（DSC）磁共振成像（MR）获得的脑血流（CBF）定量值与经确认的脑血管闭塞性疾病患者的正电子发射断层扫描（PET）参考标准。
材料与方法
对 18 例经血管造影证实的烟雾病（n = 8）或颈内动脉闭塞（n = 10）患者进行前瞻性研究，获得了局部机构审查委员会批准和知情同意。患者为 6 名男性和 12 名女性，年龄 28-71 岁，平均年龄 45 岁±10.4（标准差）。当天采集 DSC MR 图像和氧 15 标记水（H 2 [（15）O]）PET 图像。DSC 图像经后处理，生成 CBF（每 100 g/min 毫升）的参数图像，配准，并使用基于网格的感兴趣区进行分析。比较每个感兴趣区的 MR 成像和 PET 数据集的 CBF 平均值。确定每位患者的相关性，并使用线性回归分析和 Bland-Altman 图报告汇总的 MR 成像和 PET CBF 之间的总体一致性。
结果
在所有患者中，MR 成像和 PET CBF 值之间均发现强相关性（r 2 ≥0.55）。发现使用边界值法可在整个患者队列中可预测地低估 CBF（平均斜率为 0.82，标准差为 0.18，汇总数据的斜率为 0.75）。这允许对 MR 成像值进行简单的缩放，从而在汇总数据中与 PET 值产生强烈的一致性（r 2 =0.66，斜率=1.00，截距=0.00）。
结论
数据表明，边界值 MR 成像技术在 DSC MR 成像和 H 2 [（15）O] PET 之间产生相似的定量 CBF 结果。尽管 MR 衍生的 CBF 低估了 PET 衍生的 CBF，但线性 MR 和 PET 关系的斜率在患者之间的变异性明显小于竞争性定量技术。因此，在临床环境中，边界值技术似乎更可预测地测量定量 CBF。
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