慢性颈动脉闭塞性疾病中脑血流量的测量：动态磁敏感对比灌注磁共振成像与正电子发射断层扫描的比较
Measurement of cerebral blood flow in chronic carotid occlusive disease: comparison of dynamic susceptibility contrast perfusion MR imaging with positron emission tomography.
作者信息
Mukherjee Pratik, Kang Hyunseon Christine, Videen Tom O, McKinstry Robert C, Powers William J, Derdeyn Colin P
机构信息
Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA.
出版信息
AJNR Am J Neuroradiol. 2003 May;24(5):862-71.
BACKGROUND AND PURPOSE
Our purpose was to evaluate the accuracy of cerebral blood flow (CBF) measurements obtained by using dynamic susceptibility contrast-enhanced MR imaging, including the influence of arterial input function (AIF) selection, compared with those obtained by using [(15)O]-H(2)O positron emission tomography (PET) for patients with chronic carotid occlusion.
METHODS
MR images and PET scans were obtained of seven patients with unilateral carotid occlusion and were co-registered for region of interest analysis. PET CBF maps were generated by using the autoradiographic method. MR imaging CBF maps were calculated by deconvolution of the susceptibility time curve with a proximal middle cerebral artery AIF and were converted to absolute flow rates either by assuming a constant contralateral white matter CBF value of 22 mL/100 mL/min or by using individually determined PET white matter CBF values.
RESULTS
Although CBF values measured by PET and MR imaging were positively correlated for every patient, the slopes and y intercepts of the regression lines varied widely among patients. The correlation was better when individual white matter CBF values measured by PET were used to scale the white matter CBF values measured by MR imaging (r = 0.84, P <.0001) than when constant contralateral CBF values were assumed (r = 0.54, P <.0001). The choice of AIF ipsilateral or contralateral to the occluded carotid artery made no statistically significant difference (P >.05) to the correlation coefficient, slope, or y intercept of the MR imaging versus PET CBF regressions for six of the seven patients.
CONCLUSION
Although linearly correlated with CBF values measured by PET, dynamic susceptibility contrast-enhanced MR imaging was not accurate for measuring absolute CBF values. AIF selection relative to the side of carotid occlusion did not significantly affect calculated MR imaging CBF values for six of the seven patients.
背景与目的
我们的目的是评估使用动态磁敏感对比增强磁共振成像获得的脑血流量（CBF）测量值的准确性，包括动脉输入函数（AIF）选择的影响，并与使用[¹⁵O] - H₂O正电子发射断层扫描（PET）获得的慢性颈动脉闭塞患者的测量值进行比较。
方法
对7例单侧颈动脉闭塞患者进行了磁共振成像和PET扫描，并进行了感兴趣区分析的配准。PET CBF图采用放射自显影法生成。磁共振成像CBF图通过用大脑中动脉近端AIF对磁敏感时间曲线进行去卷积计算得出，并通过假设对侧白质CBF值恒定为22 mL/100 mL/min或使用单独测定的PET白质CBF值转换为绝对流速。
结果
尽管PET和磁共振成像测量的CBF值在每位患者中呈正相关，但回归线的斜率和y轴截距在患者之间差异很大。当使用PET测量的个体白质CBF值来缩放磁共振成像测量的白质CBF值时（r = 0.84，P <.0001），相关性优于假设对侧CBF值恒定时（r = 0.54，P <.0001）。对于7例患者中的6例，选择与闭塞颈动脉同侧或对侧的AIF对磁共振成像与PET CBF回归的相关系数、斜率或y轴截距没有统计学上的显著差异（P >.05）。
结论
尽管动态磁敏感对比增强磁共振成像与PET测量的CBF值呈线性相关，但在测量绝对CBF值时并不准确。对于7例患者中的6例，相对于颈动脉闭塞侧的AIF选择对计算出的磁共振成像CBF值没有显著影响。
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