Department of Pharmaceutical Sciences, Meiji Pharmaceutical University, 2-522-1, Noshio, Kiyose, Tokyo 204-8588, Japan.
Colloids Surf B Biointerfaces. 2013 Apr 1;104:1-4. doi: 10.1016/j.colsurfb.2012.11.036. Epub 2012 Dec 7.
Ternary phase diagrams of gelatin-water-methanol, gelatin-water-ethanol, and gelatin-water-propanol systems were prepared to evaluate optimal coacervation. The results of their evaluation suggested that the optimal coacervation region expands with the hydrophobicity of the added poor solvent (methanol, ethanol, 1-propanol, and 2-propanol). Microcapsules prepared based on the optimal coacervation region differed in controlled drug release among poor solvents used even when the concentration of gelatin, a membrane component, is the same. Compared with microcapsules prepared using the gelatin-water-ethanol system, those prepared using the gelatin-water-propanol system showed a 34% decrease in the drug release rate 24h after the initiation of the drug release test. These results suggested that microcapsules prepared using gelatin-water-various lower alcohol systems can readily control drug release and can be a useful drug delivery system (DDS).
明胶-水-甲醇、明胶-水-乙醇和明胶-水-丙醇三元相图的制备旨在评估最佳共凝聚。评估结果表明，最佳共凝聚区域随添加不良溶剂（甲醇、乙醇、1-丙醇和 2-丙醇）的疏水性而扩大。即使使用的膜成分明胶的浓度相同，基于最佳共凝聚区域制备的微胶囊在不同不良溶剂中的控释药物释放也存在差异。与使用明胶-水-乙醇系统制备的微胶囊相比，使用明胶-水-丙醇系统制备的微胶囊在药物释放试验开始后 24 小时内药物释放速率降低了 34%。这些结果表明，使用明胶-水-各种低级醇系统制备的微胶囊可以容易地控制药物释放，并且可以成为有用的药物递送系统（DDS）。
