Sawicka J
Lehrstuhl für Arzneimitteltechnologie, Pharmazeutische Fakultät, Medizinischen Akakemie Poznań, Polen.
Pharmazie. 1990 Apr;45(4):264-5.
Microcapsules with crystalline cholecalciferol were obtained by the use of gelatin (type A and B) as a main covering component by both simple and complex coacervation methods. The properties of the obtained microcapsules were determined by their size, release in gastric and intestinal juices, coat/core ratio, the content of cholecalciferol and its liberation. It was observed that both in the simple and complex coacervation, regardless of the type of gelatin used in the procedure, the effectiveness of the process and the properties of the microcapsules depend on coat/core ratio. In simple coacervation method optimal results were achieved when coat/core ratio was 0.25:1. In complex coacervation method optimal ratio was 0.5:1.
通过简单凝聚法和复凝聚法，以明胶（A型和B型）作为主要包衣成分，制备了含有结晶型胆钙化醇的微胶囊。通过微胶囊的尺寸、在胃液和肠液中的释放情况、包衣/核心比例、胆钙化醇含量及其释放情况来测定所制备微胶囊的性能。观察发现，无论是在简单凝聚法还是复凝聚法中，无论在该过程中使用何种类型的明胶，过程的有效性和微胶囊的性能都取决于包衣/核心比例。在简单凝聚法中，当包衣/核心比例为0.25:1时可获得最佳结果。在复凝聚法中，最佳比例为0.5:1。
