Curr Opin Lipidol. 2013 Feb;24(1):1-3. doi: 10.1097/MOL.0b013e32835c0834.
Nonalcoholic fatty liver disease (NAFLD) has emerged as a clear risk factor for cardiovascular risk. Through its association with metabolic syndrome including insulin resistance and type 2 diabetes, NAFLD certainly has strong indirect associations with cardiovascular risk. Recent population studies have strengthened the association with prevalent coronary heart disease. Investigative cardiology has shown that NAFLD is also associated with markers of subclinical atherosclerosis, such as diminished endothelial function and carotid artery intima-media thickening. Though causality between NAFLD and cardiovascular disease can only be tested in a clinical trial, these recent findings do emphasize the need to develop strategies including nutritional that may prevent NAFLD.
非酒精性脂肪性肝病（NAFLD）已成为心血管风险的明确危险因素。通过与代谢综合征相关，包括胰岛素抵抗和 2 型糖尿病，NAFLD 与心血管风险肯定有很强的间接关联。最近的人群研究加强了与普遍存在的冠心病的关联。心血管病学研究表明，NAFLD 还与亚临床动脉粥样硬化的标志物有关，如内皮功能下降和颈动脉内膜中层增厚。虽然 NAFLD 和心血管疾病之间的因果关系只能在临床试验中进行测试，但这些最近的发现确实强调了需要制定策略，包括营养策略，以预防 NAFLD。
