Camporese Alessandro
SOC di Microbiologia e Virologia, A.O. S. Maria degli Angeli, Pordenone, Italy.
Infez Med. 2012 Dec;20(4):237-44.
At present there is still a great deficit in the routine aetiological diagnosis of lower respiratory tract infections (LRTIs): in most studies more than 50% of cases have no aetiological diagnosis, resulting in prescribing unnecessary or inappropriate antibiotics. A wide variety of diagnostic procedures and techniques are applied to detect the aetiological pathogens of LRTIs. Traditional diagnostic culture methods lack sensitivity, are not feasible in many contexts, and focus only on a few of the large number of aetiological agents. Molecular methods are revolutionizing the diagnostic procedures for managing patients with LRTIs, resulting from a combination of improved sensitivity and specificity, a potential for automatisation and the production of very rapid results.
目前，下呼吸道感染（LRTIs）的常规病因诊断仍存在很大不足：在大多数研究中，超过50%的病例没有病因诊断，导致开具不必要或不适当的抗生素。人们应用了各种各样的诊断程序和技术来检测LRTIs的病原病原体。传统的诊断培养方法缺乏敏感性，在许多情况下不可行，并且只关注众多病原体中的少数几种。分子方法正在彻底改变LRTIs患者的诊断程序，这是由于其敏感性和特异性提高、具有自动化潜力以及能产生非常快速的结果。
