调控 Wnt 信号以增加或减少毛发。
Tuning Wnt signals for more or fewer hairs.
机构信息
Department of Pathology, University of Southern California, Los Angeles, CA, USA.
出版信息
J Invest Dermatol. 2013 Jan;133(1):7-9. doi: 10.1038/jid.2012.446.
Abstract
Activation of β-catenin was shown to be of central importance for hair development and cycling. Recent progress brought more understanding to how Wnt signaling is regulated during hair follicle generation and regeneration, telogen-anagen reentry, and extra-follicular macro-environmental modulation. This new understanding presents multiple possibilities to fine tune Wnt signaling for desired hair growth.
摘要
β-连环蛋白的激活对于毛发生长和循环至关重要。最近的研究进展使人们对 Wnt 信号在毛囊发生和再生、休止期-生长期再进入以及毛囊外宏观环境调节过程中的调控机制有了更深入的了解。这一新认识为精细调控 Wnt 信号以实现理想的毛发生长提供了多种可能性。
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本文引用的文献
1
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J Invest Dermatol. 2013 Jan;133(1):42-8. doi: 10.1038/jid.2012.235. Epub 2012 Jul 26.
2
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J Invest Dermatol. 2013 Jan;133(1):31-41. doi: 10.1038/jid.2012.230. Epub 2012 Jul 19.
3
Wnt5a can both activate and repress Wnt/β-catenin signaling during mouse embryonic development.Wnt5a 在小鼠胚胎发育过程中既能激活又能抑制 Wnt/β- 连环蛋白信号通路。
Dev Biol. 2012 Sep 1;369(1):101-14. doi: 10.1016/j.ydbio.2012.06.020. Epub 2012 Jul 4.
4
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Development. 2012 Apr;139(8):1522-33. doi: 10.1242/dev.076463.
5
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J Dermatol Sci. 2012 Apr;66(1):3-11. doi: 10.1016/j.jdermsci.2012.02.007. Epub 2012 Feb 24.
6
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Development. 2011 Dec;138(23):5189-99. doi: 10.1242/dev.064592. Epub 2011 Oct 26.
7
Self-organizing and stochastic behaviors during the regeneration of hair stem cells.毛发干细胞再生过程中的自组织和随机行为。
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8
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Dev Dyn. 2011 Feb;240(2):365-71. doi: 10.1002/dvdy.22541. Epub 2011 Jan 11.
9
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Proc Natl Acad Sci U S A. 2007 Jun 12;104(24):10063-8. doi: 10.1073/pnas.0703004104. Epub 2007 Jun 6.
10
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Nature. 2007 May 17;447(7142):316-20. doi: 10.1038/nature05766.
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