Department of Pathology, University of Southern California, Los Angeles, CA, USA.
J Invest Dermatol. 2013 Jan;133(1):7-9. doi: 10.1038/jid.2012.446.
Activation of β-catenin was shown to be of central importance for hair development and cycling. Recent progress brought more understanding to how Wnt signaling is regulated during hair follicle generation and regeneration, telogen-anagen reentry, and extra-follicular macro-environmental modulation. This new understanding presents multiple possibilities to fine tune Wnt signaling for desired hair growth.
β-连环蛋白的激活对于毛发生长和循环至关重要。最近的研究进展使人们对 Wnt 信号在毛囊发生和再生、休止期-生长期再进入以及毛囊外宏观环境调节过程中的调控机制有了更深入的了解。这一新认识为精细调控 Wnt 信号以实现理想的毛发生长提供了多种可能性。
