Prouzová Z, Brychtová S
Ustav klinicke a molekularni patologie LF UP a FN Olomouc.
Klin Onkol. 2012;25(6):471-5.
Paraneoplastic neurological syndromes are rare conditions manifest as psychiatric/neurological symptoms. They are caused by autoimmunne cross-reaction leading to destruction of the central nervous system.
We present the case of a 64-year-old patient hospitalized for 6 months at the Department of Psychiatry for persisting depression. During that time he progressed to delirium. A diagnosis of diffuse encephalopathy was made, but further examination revealed a small cell lung cancer with generalisation. A paraneoplastic syndrome was finally diagnosed after autoptic and histologic examination.
Paraneoplastic neurological syndromes can be early signs of malignancy and may considerably precede oncologic diagnosis.
副肿瘤性神经系统综合征是罕见疾病，表现为精神/神经症状。它们由自身免疫交叉反应引起，导致中枢神经系统破坏。
我们报告一例64岁患者，因持续性抑郁在精神科住院6个月。在此期间，他发展为谵妄。诊断为弥漫性脑病，但进一步检查发现有广泛转移的小细胞肺癌。经尸检和组织学检查后最终诊断为副肿瘤综合征。
副肿瘤性神经系统综合征可能是恶性肿瘤的早期迹象，且可能在肿瘤诊断之前很长时间出现。
