Jerusalem Institute of Aging Research, Hadassah-Hebrew University Medical Center and Hebrew University-Hadassah Medical School, Jerusalem, Israel.
J Am Geriatr Soc. 2013 Jan;61(1):40-5. doi: 10.1111/jgs.12060. Epub 2013 Jan 10.
To examine the relationship between resting pulse rate (RPR) and longevity in individuals aged 70 to 90.
The Jerusalem Longitudinal Cohort Study (1990-2010) is a prospective longitudinal study of a representative cohort born in 1920-21.
Home-based comprehensive assessment in 1990, 1998, and 2005.
Individuals aged 70 (n = 453), 78 (n = 856), and 85 (n = 1,044), with follow-up to age 90.
Comprehensive assessment included average RPR, beta-blocker usage, and physical activity level. Mortality data were collected from the Ministry of Interior from 1990 to 2010.
Cox proportional hazards ratios (HRs) were determined for RPR (continuous variable), adjusting for sex, education, diabetes mellitus, ischemic heart disease, congestive heart failure, hypertension, kidney disease, anemia, physical activity, body mass index, self-rated health, dementia, beta-blocker use, and an interaction term for RPR by beta-blocker use.
Mean RPR was 75.1 ± 9.9 at 70, 74.5 ± 10.9 at 78, and 68.5 ± 10.5 at 85 in women and 74.3 ± 10.7 at 70, 73.1 ± 11.2 at 78, and 65.2 ± 10.5 at 85 in men, with a significant decline from 78 to 85 for both sexes. In participants not taking beta-blockers followed up from 70 to 77, 78 to 84, and 85 to 90, mean RPR was lower in survivors than nonsurvivors for women (75.8 ± 9.2 vs 83.5 ± 10.9, P < .001; 75.2 ± 9.8 vs 79.9 ± 12.6, P = .004; 71.5 ± 9.9 vs 74.6 ± 10.7, P = .02, respectively) and men (75.2 ± 10.3 vs 75.2 ± 10.9, P = .98; 73.5 ± 10.1 vs 77.2 ± 12.1, P = .005; 67.1 ± 9.5 vs 70.4 ± 11.7, P = .01, respectively). Adjusted HRs for mortality per 10-beat increase in RPR during follow-up were 1.13 (95% confidence interval (CI) = 0.87-1.47) for 70 to 77, 1.35 (95% CI = 1.11-1.65) for 78 to 84, and 1.17 (95% CI = 1.01-1.37) for 85 to 90.
RPR declines in the oldest old, and this decline is associated with greater longevity. It may serve as a simple prognostic marker in the oldest old.
研究 70 至 90 岁人群的静息心率 (RPR) 与长寿之间的关系。
耶路撒冷纵向队列研究 (1990-2010) 是一项对 1920-21 年出生的代表性队列进行的前瞻性纵向研究。
1990 年、1998 年和 2005 年进行家庭综合评估。
年龄分别为 70 岁 (n = 453)、78 岁 (n = 856) 和 85 岁 (n = 1044) 的个体，随访至 90 岁。
综合评估包括平均 RPR、β受体阻滞剂的使用和身体活动水平。1990 年至 2010 年期间从内政部收集死亡率数据。
使用 Cox 比例风险比 (HR) 确定 RPR (连续变量)，调整性别、教育程度、糖尿病、缺血性心脏病、充血性心力衰竭、高血压、肾脏疾病、贫血、身体活动、体重指数、自我报告的健康状况、痴呆、β受体阻滞剂的使用以及 RPR 与 β受体阻滞剂使用的交互项。
女性在 70 岁时的平均 RPR 为 75.1 ± 9.9，78 岁时为 74.5 ± 10.9，85 岁时为 68.5 ± 10.5，男性在 70 岁时为 74.3 ± 10.7，78 岁时为 73.1 ± 11.2，85 岁时为 65.2 ± 10.5，从 78 岁到 85 岁，男女 RPR 均显著下降。在未服用β受体阻滞剂的参与者中，从 70 岁随访至 77 岁、78 岁至 84 岁和 85 岁至 90 岁，女性幸存者的平均 RPR 低于非幸存者 (75.8 ± 9.2 比 83.5 ± 10.9，P <.001；75.2 ± 9.8 比 79.9 ± 12.6，P =.004；71.5 ± 9.9 比 74.6 ± 10.7，P =.02)，男性幸存者的平均 RPR 也低于非幸存者 (75.2 ± 10.3 比 75.2 ± 10.9，P =.98；73.5 ± 10.1 比 77.2 ± 12.1，P =.005；67.1 ± 9.5 比 70.4 ± 11.7，P =.01)。随访期间 RPR 每增加 10 次心跳的死亡调整 HR 分别为 70 至 77 岁为 1.13 (95%置信区间 (CI) = 0.87-1.47)，78 至 84 岁为 1.35 (95% CI = 1.11-1.65)，85 至 90 岁为 1.17 (95% CI = 1.01-1.37)。
静息心率在最年长的人群中下降，这种下降与长寿有关。它可能成为最年长人群的简单预后标志物。
