Department of Geriatrics and Rehabilitation, Hadassah-Hebrew University Medical Center, Mount-Scopus, Jerusalem, Israel.
J Am Geriatr Soc. 2009 Dec;57(12):2232-8. doi: 10.1111/j.1532-5415.2009.02567.x. Epub 2009 Nov 17.
To examine the association between body mass index (BMI) and mortality in older people.
A longitudinal cohort study of an age-homogenous, representative sample born in 1920/21.
Community-based home assessments.
West Jerusalem residents born in 1920/21 examined at baseline in 1990 (n=447), with additional recruitment waves in 1998 (n=870) and 2005 (n=1,086).
Comprehensive assessment of health variables including BMI (m/kg(2)) at ages 70, 78, and 85. The primary outcome of mortality was collected from age 70 to 88 (1990-2008). Adjusted Cox proportional hazards analysis was used to calculate hazard ratios (HRs) for mortality according to unit increase in BMI.
A unit increase in BMI in women resulted in HRs of 0.94, (95% confidence interval (CI)=0.89-0.99) at age 70, 0.95 (95% CI=0.91-0.98) at age 78, and 0.91 (95% CI=0.86-0.98) at age 85. Similarly, in men, HRs were 0.99 (95% CI=0.95-1.05) at age 70, 0.94 (95% CI=0.91-0.98) at age 78, and 0.91 (95% CI=0.86-0.98) at age 85. A time-dependent analysis of 450 subjects followed for 18 years confirmed the above findings; a unit increase in BMI resulted in HRs of 0.93 (95% CI=0.87-0.99) in women and 0.93(95% CI=0.88-0.98) in men. Eliminating the first third of follow-up mortality to account for possibility of reverse causality did not change the results.
Higher BMI was associated with lower mortality from age 70 to 88.
研究体重指数（BMI）与老年人死亡率之间的关系。
对出生于 1920/21 年的同质年龄、代表性样本进行的纵向队列研究。
社区家庭评估。
1990 年基线检查时，出生于 1920/21 年的西耶路撒冷居民（n=447），并在 1998 年（n=870）和 2005 年（n=1086）进行了额外的招募。
健康变量的全面评估，包括 70、78 和 85 岁时的 BMI（m/kg(2)）。死亡率的主要结果从 70 岁到 88 岁（1990-2008 年）进行收集。采用调整后的 Cox 比例风险分析，根据 BMI 的单位增加计算死亡率的风险比（HRs）。
女性 BMI 每增加一个单位，70 岁时的 HRs 为 0.94（95%置信区间（CI）=0.89-0.99），78 岁时为 0.95（95% CI=0.91-0.98），85 岁时为 0.91（95% CI=0.86-0.98）。同样，男性 70 岁时的 HRs 为 0.99（95% CI=0.95-1.05），78 岁时为 0.94（95% CI=0.91-0.98），85 岁时为 0.91（95% CI=0.86-0.98）。对 18 年随访的 450 名受试者进行的时间依赖性分析证实了上述发现；BMI 每增加一个单位，女性的 HRs 为 0.93（95% CI=0.87-0.99），男性为 0.93（95% CI=0.88-0.98）。消除前 1/3 的随访死亡率以考虑可能的反向因果关系，并未改变结果。
BMI 较高与 70 至 88 岁期间的死亡率降低相关。
