Melanoma of the uveal tract is most common primary intraocular cancer in adults. Approximately 50% of patients with uveal melanoma died from metastasis, irrespective of the type of treatment. Enucleation was the primary form of treatment and the best option. Whether the enucleation of the eye containing uveal melanoma accelerates metastatic death has long been a controversial topic. The combination of pathological and some experimental studies in progress concerning this contentious topic is discussed in the current article.