纤维蛋白胶辅助板层角膜移植术治疗角膜溃疡

[Fibrin glue-assisted lamellar keratoplasty for the treatment of corneal ulcer].

作者信息

Wu Hu-ping, Dong Nuo, Xie Su-zhen, Li Xue-zhi, Wang Shen

机构信息

Ocular Surface and Corneal Disease Department, Affiliated Xiamen Eye Center of Xiamen University, Xiamen 361001, China.

出版信息

Zhonghua Yan Ke Za Zhi. 2012 Nov;48(11):1011-4.

PMID:23302276

Abstract

OBJECTIVE

To investigated the feasibility of fibrin glue-assisted sutureless lamellar keratoplasty (LK) in patients with corneal ulcer.

METHODS

Noncomparative interventional case series. In 21 eyes of 21 patients with terriens marginal degeneration (TMD) or corneal ulcer after trauma, sutureless lamellar keratoplasty (LK) using fibrin glue was performed. Postoperatively, the graft status, graft clarity, the visual prognosis and postoperative complications were recorded.

RESULTS

There were 16 cases suffered with Terriens marginal degeneration (TMD) and 5 cases with corneal ulcer after foreign body removed. All the corneal ulcers were successfully healed after the procedure, the operative complications included corneal perforation during operation in 1 case, recurrence of TMD in 1 case and graft opacity in 2 cases. There was no graft dislocation, hydrops between graft and recipient interface, secondary infection and graft rejection after surgery, 19 cases had improved best-corrected visual acuity (BCVA) while 2 cases had poor vision acuity due to graft opacity (t = -2.587, P = 0.018).

CONCLUSION

Fibrin glue-assisted sutureless LK showed excellent graft stability in all patients.

摘要

目的

探讨纤维蛋白胶辅助下无缝线板层角膜移植术（LK）治疗角膜溃疡患者的可行性。

方法

非对照性干预病例系列。对21例患有Terrien边缘变性（TMD）或外伤后角膜溃疡的患者的21只眼行纤维蛋白胶辅助下无缝线板层角膜移植术。术后记录植片情况、植片清晰度、视力预后及术后并发症。

结果

16例患有Terrien边缘变性（TMD），5例为异物取出后角膜溃疡。术后所有角膜溃疡均成功愈合，手术并发症包括术中角膜穿孔1例、TMD复发1例、植片混浊2例。术后无植片脱位、植片与受体界面积液、继发感染及植片排斥反应，19例最佳矫正视力（BCVA）提高，2例因植片混浊视力差（t = -2.587，P = 0.018）。