从八角果实中分离得到的一个新苯丙素糖苷。

A new phenylpropanoid glycoside from the fruits of Illicium simonsii.

机构信息

Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China.

出版信息

Chin J Nat Med. 2012 Jan;10(1):20-3. doi: 10.1016/S1875-5364(12)60004-1.

DOI:10.1016/S1875-5364(12)60004-1

PMID:23302524

Abstract

AIM

To study the constituents and bioactivity of Illicium simonsii.

METHODS

The extracts of the fruits of Illicium simonsii were submitted to a combination of chromatographic materials, silica gel, ODS column chromatography and finally preparative HPLC to obtain eight compounds which were further evaluated for their cytotoxicity by MTT method.

RESULTS

A new phenylpropanoid glycolside, 2, 4-dihydroxy-allylbenzene-2-O-β-D-glucopyranoside (1), together with seven characteristic sesquiterpene lactones, oligandrumin B (2), oligandrumin D (3), anisatin (4), veranisatin D (5), pseudomajucin (6), 1α-hydroxy-3-deoxy-pseudoanisatin (7), 8α-hydroxy-10-deoxycyclomerrillianolide (8) were isolated.

CONCLUSION

Compound 1 is new. Compounds 1, 2, 3, 5-8 were isolated from this plant for the first time. None of the isolates showed inhibitory effects on the growth of non-small cell lung tumor cell line A549.

摘要

目的

研究八角茴香的化学成分和生物活性。

方法

采用硅胶、ODS 柱色谱和制备高效液相色谱等多种色谱材料对八角茴香果实提取物进行分离，得到 8 个化合物，并采用 MTT 法对其细胞毒性进行评价。

结果

从八角茴香中分离得到一个新的苯丙素类化合物 2,4-二羟基烯丙基苯-2-O-β-D-吡喃葡萄糖苷（1），以及 7 个特征倍半萜内酯化合物 oligandrumin B（2）、oligandrumin D（3）、anisatin（4）、veranisatin D（5）、pseudomajucin（6）、1α-羟基-3-去氧-伪阿枯米定（7）、8α-羟基-10-去氧环麦里醇内酯（8）。