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大戟属果实中的倍半萜。

Sesquiterpenes from the fruits of maxim.

机构信息

Department of Pharmacy, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu Province, China.

Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.

出版信息

Nat Prod Res. 2020 Apr;34(7):903-908. doi: 10.1080/14786419.2018.1538222. Epub 2019 Mar 11.

Abstract

A new allo-cedrane sesquiterpene glycoside () and nine known compounds (-) were isolated from the ethanol extract of the fruit of Maxim. Their structures were elucidated by spectroscopic methods, including 1D-, 2D-NMR, and HRESIMS. The absolute configuration of compound was confirmed by CD experiments. Among them, compounds , , , and displayed moderate anti-inflammatory activities by use of an in vitro bioassay.

摘要

从三叶木通果实的乙醇提取物中分离得到了一个新的 allo-cedrane 倍半萜糖苷()和九个已知化合物(-)。通过包括 1D-NMR、2D-NMR 和 HRESIMS 在内的光谱方法阐明了它们的结构。通过 CD 实验确定了化合物的绝对构型。其中,化合物、、、和表现出中等的抗炎活性,这是通过体外生物测定得到的。

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