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裂环-前泽泻烷型倍半萜的化学成分与药理活性

Chemical composition and pharmacological activity of seco-prezizaane-type sesquiterpenes.

作者信息

Jin Ye, Xie Yanqing, Zhang Peng, Khan Afsar, Zhou Zhihong, Liu Lu

机构信息

Yunnan Yunzhong Institute of Nutrition and Health, Yunnan University of Chinese Medicine, Kunming 650500, China.

Department of Chemistry, COMSATS University Islamabad, Abbottabad Campus, Abbottabad 22060, Pakistan.

出版信息

Chin Herb Med. 2023 Dec 11;16(1):70-81. doi: 10.1016/j.chmed.2023.06.003. eCollection 2024 Jan.

DOI:10.1016/j.chmed.2023.06.003
PMID:38375047
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10874773/
Abstract

The seco-prezizaane-type sesquiterpenes (SPS), as a special class of sesquiterpenes with a highly oxidative five-ring cage structure and seven consecutive chiral centers, are isolated from the genus , which have a variety of biological activities, including neurotoxicity and neurotrophic effects, etc. This review summarizes the chemical constituents and pharmacological effects of SPS, and discusses the potential trend and scope of future research.

摘要

裂环-普雷齐赞烷型倍半萜（SPS）作为一类特殊的倍半萜，具有高度氧化的五环笼状结构和七个连续的手性中心，从该属植物中分离得到，具有多种生物活性，包括神经毒性和神经营养作用等。本文综述了SPS的化学成分和药理作用，并探讨了未来研究的潜在趋势和范围。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1799/10874773/c71db553369b/gr9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1799/10874773/735cc3b95133/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1799/10874773/890a8f2b5689/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1799/10874773/215805656b73/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1799/10874773/2b02e11d8401/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1799/10874773/ddf6807e8936/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1799/10874773/c71db553369b/gr9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1799/10874773/735cc3b95133/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1799/10874773/890a8f2b5689/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1799/10874773/215805656b73/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1799/10874773/2b02e11d8401/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1799/10874773/ddf6807e8936/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1799/10874773/c71db553369b/gr9.jpg

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本文引用的文献

1
[A new seco-prezizaane-type sesquiterpene lactone from stems and branches of Illicium ternstroemioides].[从红茴香茎枝中分离得到的一种新的裂环-prezizaane型倍半萜内酯]
Zhongguo Zhong Yao Za Zhi. 2021 Nov;46(22):5848-5852. doi: 10.19540/j.cnki.cjcmm.20210525.201.
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seco-Prezizanne Sesquiterpenes and Prenylated C6-C3 Compounds from the Fruits of Illicium lanceolatum A. C. Smith.八角果实中的 sec o-Prezizanne 倍半萜和 C6-C3 类的类异戊二烯化合物
Chem Biodivers. 2022 Jan;19(1):e202100868. doi: 10.1002/cbdv.202100868. Epub 2021 Dec 22.
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Highly oxidized sesquiterpenes from the fruits of Illicium lanceolatum A. C. Smith.
来自八角莲果实的高度氧化倍半萜。
Phytochemistry. 2020 Apr;172:112281. doi: 10.1016/j.phytochem.2020.112281. Epub 2020 Feb 7.
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[Investigation on seco-prezizaane sesquiterpenes from fruits of Illicium lanceolatum and their neuroprotection activity].[八角莲果实中裂环-prezizaane倍半萜类化合物及其神经保护活性的研究]
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Diastereoselective Methylation at the Congested β-Position of a Butenolide Ring: Studies toward the Synthesis of -Prezizaane-Type Sesquiterpenes.高拥挤β-位烯丙醇内酯环的非对映选择性甲基化：-Prezizaane 型倍半萜合成研究。
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